Scientists have developed a simple test that can identify 18 early-stage cancers that experts say could represent a medical “gamechanger.”
Cancer accounts for one in every six deaths worldwide, but early detection can significantly improve outcomes.
Existing screening tests have drawbacks, including invasiveness, cost and low levels of accuracy for early stage disease.
Photo: EPA-EFE
Now US researchers have designed a test that analyses proteins in the blood and can pick up 18 early stage cancers, representing all main organs in the human body.
Specific blood proteins could already be used for early detection and monitoring, but until now tests have lacked sensitivity — accuracy of picking up those with cancer — and specificity — accuracy of excluding those without cancer, the researchers said.
The team, from the US biotech firm Novelna, said their test outperformed others relying on tumor DNA in the blood, and had “a sensitivity much greater” than the Galleri test being trialed on the NHS in the UK.
Photo: AFP
By looking at proteins in blood plasma, the experts were able to differentiate cancer samples from normal ones, and even distinguish between different types of cancers “with high accuracy,” they said. The research also found evidence that cancer protein signals were likely to be sex-specific.
Writing in the journal BMJ Oncology, the team said: “This finding is the foundation for a multi-cancer screening test for the early detection of 18 solid tumors that cover all major human organs of origin for such cancers at the earliest stage of their development with high accuracy.”
They added: “This could re-shape screening guidelines, making this plasma test a standard part of routine check-ups.”
Photo: AP
“These findings pave the way for a cost-effective, highly accurate, multi-cancer screening test that can be implemented on a population-wide scale.”
Blood plasma samples were collected from 440 people diagnosed with 18 different types of cancer, and from 44 healthy blood donors.
The team then identified proteins which showed early stage cancers and where they originated in the body “with high accuracy.”
The team wrote: “At stage I (the earliest cancer stage) and at the specificity of 99 percent, our panels were able to identify 93 percent of cancers among males and 84 percent of cancers among females.
“Our sex-specific localization panels consisted of 150 proteins and were able to identify the tissue of origin of most cancers in more than 80 percent of cases.”
Analysis of the plasma protein also showed almost all of them were present at very low levels. This shows the importance of low-level proteins to pick up pre-cancerous and early stage disease before a tumor has had time to cause substantial damage, the team said.
But the team said their relatively small sample size meant further studies were needed in bigger groups of people.
Mangesh Thorat, of the Centre for Cancer Prevention at the Wolfson Institute of Preventive Medicine, who was not involved with the study, said there remained questions about the test and more studies were needed.
“However, the interesting aspects of this assay are a much higher sensitivity for stage I cancers than other similar assays in development and gender-specific performance differences which are biologically and clinically relevant,” he said.
“If the assay performance in future, well-designed sequential studies is anywhere close to what this preliminary study suggests, then it could really be a gamechanger.”
Prof Paul Pharoah, a cancer epidemiology expert at Cedars-Sinai Medical Center, who was also not involved in the study, welcomed the findings but urged caution.
“Simple blood tests that can detect many different cancers in the early stages (test is sensitive) and do not generate false positives (test is specific) are a holy grail for early detection,” he said.
“This paper reports on the initial results of the development of one such test. While the results show some promise, it is far too soon to be confident that this test will turn out to be useful for early cancer detection.”
Last week saw the appearance of another odious screed full of lies from the People’s Republic of China (PRC) Ambassador to Australia, Xiao Qian (肖千), in the Financial Review, a major Australian paper. Xiao’s piece was presented without challenge or caveat. His “Seven truths on why Taiwan always will be China’s” presented a “greatest hits” of the litany of PRC falsehoods. This includes: Taiwan’s indigenous peoples were descended from the people of China 30,000 years ago; a “Chinese” imperial government administrated Taiwan in the 14th century; Koxinga, also known as Cheng Cheng-kung (鄭成功), “recovered” Taiwan for China; the Qing owned
In Taiwan’s politics the party chair is an extremely influential position. Typically this person is the presumed presidential candidate or serving president. In the last presidential election, two of the three candidates were also leaders of their party. Only one party chair race had been planned for this year, but with the Jan. 1 resignation by the currently indicted Ko Wen-je (柯文哲) of the Taiwan People’s Party (TPP) two parties are now in play. If a challenger to acting Chairman Huang Kuo-chang (黃國昌) appears we will examine that race in more depth. Currently their election is set for Feb. 15. EXTREMELY
Jan. 20 to Jan. 26 Taipei was in a jubilant, patriotic mood on the morning of Jan. 25, 1954. Flags hung outside shops and residences, people chanted anti-communist slogans and rousing music blared from loudspeakers. The occasion was the arrival of about 14,000 Chinese prisoners from the Korean War, who had elected to head to Taiwan instead of being repatriated to China. The majority landed in Keelung over three days and were paraded through the capital to great fanfare. Air Force planes dropped colorful flyers, one of which read, “You’re back, you’re finally back. You finally overcame the evil communist bandits and
They increasingly own everything from access to space to how we get news on Earth and now outgoing President Joe Biden warns America’s new breed of Donald Trump-allied oligarchs could gobble up US democracy itself. Biden used his farewell speech to the nation to deliver a shockingly dark message: that a nation which has always revered its entrepreneurs may now be at their mercy. “An oligarchy is taking shape in America of extreme wealth, power and influence that literally threatens our entire democracy, our basic rights and freedoms,” Biden said. He named no names, but his targets were clear: men like Elon Musk
RSS