The chain breaks here, in a tiny medical clinic in Burkina Faso that went nearly a year without a working refrigerator.
From factory to syringe, the world’s most promising COVID-19 vaccine candidates need non-stop sterile refrigeration to stay potent and safe, but despite enormous strides in equipping developing countries to maintain the vaccine “cold chain,” nearly 3 billion of the world’s 7.8 billion people live where temperature-controlled storage is insufficient for an immunization campaign to bring the pandemic under control.
As a result, poor people around the world who were among the hardest hit by the COVID-19 pandemic are also likely to be the last to recover from it.
Illustration: Mountain People
The vaccine-cold-chain hurdle is just the latest disparity of the pandemic weighted against the poor, who more often live and work in crowded conditions that allow the coronavirus to spread, have little access to medical oxygen, which is vital to COVID-19 treatment, and whose health systems lack labs, supplies or technicians to carry out large-scale testing.
Maintaining the cold chain for coronavirus vaccines would not be easy even in the richest of countries, especially when it comes to vaccines requiring ultra-cold temperatures of about minus-70°C. Investment in infrastructure and cooling technology lags behind the high-speed leap that vaccine development has taken this year due to the coronavirus.
With the pandemic in its 10th month, logistics experts warn that vast parts of the world lack the refrigeration to administer an effective vaccination program. This includes most of central Asia, much of India and Southeast Asia, Latin America, except for the largest countries, and all but a tiny corner of Africa.
The medical clinic outside Burkina Faso’s capital, a dirt-streaked building that serves a population of 11,000, is a microcosm of the obstacles.
After its refrigerator broke last fall, the clinic could no longer keep vaccines against tetanus, yellow fever, tuberculosis and other common diseases on site, nurse Julienne Zoungrana said.
Personnel instead used motorbikes to fetch vials in insulated carriers from a hospital in Ouagadougou, making a 40-minute round-trip drive on a narrow road that varies between dirt, gravel and pavement.
A mother of two who visits the clinic in Gampela said that she thinks a coronavirus inoculation program would be challenging in her part of the world.
Adama Tapsoba, 24, walks four hours under scorching sun to get her baby his routine immunizations and often waits hours more to see a doctor. A week earlier, her five-month-old son had missed a scheduled shot because Tapsoba’s daughter was sick and she could only bring one child on foot.
“It will be hard to get a [COVID-19] vaccine,” Tapsoba said, bouncing her son on her lap outside the clinic. “People will have to wait at the hospital and they might leave without getting it.”
To uphold the cold chain in developing nations, international organizations have overseen the installation of tens of thousands of solar-powered vaccine refrigerators.
Keeping vaccines at stable temperatures from the time they are made until they are given to patients also requires mobile refrigeration, reliable electricity, maintained roads and, above all, advance planning.
For poor countries such as Burkina Faso, the best chance of receiving a coronavirus vaccine is through a global initiative called COVAX, which is led by the WHO and Gavi, the Vaccine Alliance. The goal of COVAX is to place orders for multiple promising vaccine candidates and allocate the successful ones equitably.
The UN International Children’s Emergency Fund (UNICEF) began laying the global distribution groundwork months ago, in Copenhagen. At the world’s largest humanitarian aid warehouse, logistics personnel are trying to foresee shortages by learning from the past, especially the spring chaos surrounding global shortages of masks and other protective gear, which were often commandeered off airport tarmacs, or stolen and traded on the black market.
Forty-two coronavirus vaccine candidates are in clinical trials and another 151 are in preclinical evaluation, the WHO said.
The ones most likely to end up in the COVAX mix must be stored at 2°C to 8°C.
A Pfizer candidate is among the ones in advanced testing requiring storage at ultra-cold temperatures. The company — which has designed a special carrying case for its vaccine — has expressed interest in COVAX and signed contracts with the US, Europe and Japan.
Medical freezers that go down to minus-70°C are rare even in US and European hospitals. Many experts believe that west African countries that suffered through a 2014-2016 Ebola outbreak might be the best positioned, because a vaccine against that coronavirus also requires ultra-cold storage.
However, for more than two-thirds of the world, the advanced technology is nowhere on the horizon, a study by German logistics company DHL showed.
Billions of people are in countries that do not have the necessary infrastructure to maintain the cold chain for either existing vaccines or more conventional coronavirus candidates, it said.
Opportunities for vaccines to be lost expand the farther a vaccine travels. DHL estimated that 15,000 cargo flights would be required to vaccinate the entire planet against COVID-19, stretching global capacity for aircraft and potentially supplies of materials such as dry ice.
“We need to find a bridge” for every gap in the cold chain, DHL chief commercial officer Katja Busch said. “We’re talking about investments... As a society, this is something we have to do.”
Gavi and UNICEF worked before the pandemic to supply much of Africa and Asia with refrigeration for vaccines, fitting out 40,000 facilities since 2017.
UNICEF is offering governments a checklist of what they would need to maintain a vaccine supply chain and asking them to develop a plan.
“The governments are in charge of what needs to happen in the end,” said Benjamin Schreiber, who is among the directors of UNICEF’s vaccination program.
Cracks in the global cold chain start once vaccines leave the factory. Container ships are not equipped to refrigerate pharmaceutical products with a limited shelf life. Shipping vaccines by air costs a lot more and air cargo traffic is only now rebounding from pandemic-related border closures.
Even when flights are cold and frequent enough, air freight carries other potential hazards. The WHO estimates that as much as half of vaccines globally are lost to wastage, sometimes due to heat exposure or vials breaking while in transit.
With coronavirus vaccines, which are to become one of the world’s most sought-after products, theft would also be a danger.
“They can’t be left on a tarmac and fought over because they would actually be spoiled and they would have no value — or, worse still, people would still be trying to distribute them,” International Air Transport Association global cargo head Glyn Hughes said.
Creativity is needed to keep the cold chain intact, as coronavirus vaccines are distributed on a global scale, said Johns Hopkins University researcher Dai Tinglong (戴廷龍), who specializes in healthcare logistics.
Gavi and UNICEF have experimented with delivering vaccines by drone, while Indian officials have floated the idea of setting aside part of the country’s vast food storage network for the coronavirus vaccines.
“If people can figure out how to transport ice cream, they can transport vaccines,” Dai said.
Temperature-sensitive labels that change color when a vaccine is exposed to heat too long and no longer safe to use, and real-time delivery tracking to ensure that vaccines reach their destinations as intended have allowed for progress in delivering safe shots.
Yet chances for something to go wrong multiply on the ground as vaccines are prepped to leave national depots. Since the cold chain is so fragile, logistics planning is crucial. Syringes and disposal boxes must be available as soon as vaccine shipments arrive.
By the end of the year, UNICEF expects to have 520 million syringes prepositioned for coronavirus vaccines in the developing world and maps of where the refrigeration needs are greatest to “ensure that these supplies arrive in countries by the time the vaccines do,” UNICEF executive director Henrietta Fore said.
The last vaccine requiring cold storage that India’s national program adopted was for rotavirus, a stomach bug that typically affects babies and young children.
Gagandeep Kang, who led the research for that vaccine, estimated that India has about 30 percent less storage capacity than it would need for a coronavirus vaccine.
In countries such as India and Burkina Faso, a lack of public transportation presents another obstacle to getting citizens inoculated before vaccines go bad.
Patients must walk for hours to receive healthcare, said Aquinas Edassery, who runs two clinics in one of India’s poorest and least-developed regions.
The trip on a single road that winds 86km over steep hills and washes out for months at a time would pose an insurmountable barrier for many residents of the eastern district of Rayagada, Edassery said.
As with most logistics, the last kilometer is the hardest part of delivering a coronavirus vaccine to the people who need it. Venezuela provides a glimpse into how the vaccine cold chain could go dramatically off course.
When a blackout last year left much of the nation in the dark for a week, doctors in several parts of Venezuela reported losing stocks of vaccines.
The country’s largest children’s hospital had to discard thousands of doses of vaccines for illnesses such as diphtheria, Venezuelan Society of Childcare and Pediatrics head Huniades Urbina said.
“We won’t be able to halt either the coronavirus or measles,” Urbina said.
Preserving the cold chain has only grown more difficult since then. Gas shortages limit the ability to move vaccines quickly from one part of Venezuela to another, dry ice to keep vaccines cool during transport is harder to find and after years of economic decline, there are fewer doctors and other professionals trained to keep the chain intact.
“I’m not optimistic on how the vaccine would be distributed in the inner states, because there is no infrastructure of any kind to guarantee delivery — or if it gets delivered, guarantees adequate preservation under cold conditions,” pathologist Alberto Paniz-Mondolfi said.
Venezuela presents an extreme example, but a coronavirus vaccine is also likely to challenge parts of Latin America with more robust healthcare systems. In Peru, private businesses that typically transport fish and beef have offered their trucks, although it remains unclear whether the Peruvian Ministry of Health would accept.
After the refrigerator went out at the clinic in Gampela, vaccination days became an ordeal, nurse Zoungrana said.
Personnel on hospital courier runs must buy fuel that they often cannot afford, and make a second trip to and from the capital to return any unused doses.
“We’re suffering,” said Zoungrana, who was run off the road on her motorbike just a few weeks ago.
Days after reporters visited the clinic this month, a long-awaited solar refrigerator arrived. With technicians in short supply, the clinic was waiting to be sure that the appliance would function properly before stocking it with vaccines.
Nationwide, Burkina Faso is about 1,000 clinical refrigerators short, and less than 40 percent of the health facilities that conduct vaccinations have reliable refrigerators, national vaccination director Issa Ouedraogo said.
Multi-dose vials — the equivalent of bulk storage for vaccines — could drastically reduce global transportation costs, but once a vial is opened, its shelf life counts down even faster. If too few people show up in time for their shots, whatever remains in the larger vials must be discarded.
“It’s really upsetting to have wastage like that. It’ll result in loss of lives and pain and suffering. It’s a waste of resources,” said University of Massachusetts at Amherst professor Anna Nagurney, who studies supply chain logistics.
UNICEF is betting on 20-dose vials of coronavirus vaccine and hoping that the amount wasted would stay below 3 percent for closed vials and 15 percent for open multi-dose vials that do not get used up, said Michelle Siedel, one of UNICEF’s cold chain equipment platform optimization managers.
If Burkina Faso were given 1 million doses of a coronavirus vaccine today, the country could not handle it, said Jean-Claude Mubalama, UNICEF’s head of health and nutrition for the country.
“If we had to vaccinate against the coronavirus now, at this moment, it would be impossible,” he said.
I think it is fair to say there is a widespread sigh of relief among many Americans — particularly those of us focused on foreign policy — that the chaotic and unpredictable Trump years will soon be over. Mr. Trump brought little real knowledge or experience to his foreign policy, and it showed. He also — in my humble opinion — did not err on the side of expertise in his choice of top foreign policy officials. Nor was he particularly open to listening to advice. All in all a poor set of traits for overseeing the complex foreign policy
After more than eight years of talks, the Regional Comprehensive Economic Partnership (RCEP) was signed on Nov. 15, combining the individual free-trade agreements signed between ASEAN member states on the one hand, and China, Japan, South Korea, Australia and New Zealand on the other. Under the leadership of ASEAN and China, most observers did not expect the RCEP to provide a high degree of openness, and the announced agreement lives up to these expectations, containing few surprises. All products covered by the RCEP tariff reductions are agricultural and industrial products, but reductions of agricultural product tariffs are very limited, for example covering
While the nation grapples with its falling birthrate, it is also imperative to address how parents are raising their children. The phenomenon of “dinosaur parents” — who lash out at teachers, store staff or people on the street when confronted about their children misbehaving — has been an issue for a while, but there seems to be an uncomfortably high number of incidents making the news lately. On Saturday, a preschool teacher on an online forum wrote about a mother who often visited the school and screamed at the staff for various reasons — including her child being late to school
On Nov. 14, Taipei Mayor Ko Wen-je (柯文哲) commented on the nation’s low birthrate, claiming that young people would surely have children if only they married first, and that the low marriage rate among young people is the cause of the rapid aging of Taiwan’s society. The Taipei City Government therefore proposed to offer subsidies to couples willing to marry. Ko’s comment stirred up a great deal of protest. As a sociology student, I would like to remind the mayor that his remarks not only decontextualized the population aging issue, but also oversimplified the low birthrate problem. First, a look at systemic