Wed, Jan 15, 2020 page6

• Scientists use stem cells from frogs to build living robots

  • The Guardian
  • • 
    • 
    • 

  Be warned. If the rise of the robots comes to pass, the apocalypse might be a more squelchy affair than science fiction writers have prepared us for.

  Researchers in the US have created the first living machines by assembling cells from African clawed frogs into tiny robots that move around under their own steam.

  One of the most successful creations has two stumpy legs that propel it along on its “chest.” Another has a hole in the middle that researchers turned into a pouch so that it could shimmy around with miniature payloads.

  “These are entirely new lifeforms. They have never before existed on Earth,” said Michael Levin, the director of the Allen Discovery Center at Tufts University in Medford, Massachusetts. “They are living, programmable organisms.”

  Roboticists tend to favor metal and plastic for their strength and durability, but Levin and his colleagues see benefits in making robots from biological tissues. When damaged, living robots can heal their wounds, and once their task is done they fall apart, just as natural organisms decay when they die.

  Their unique features mean that future versions of the robots might be deployed to clean up microplastic pollution in the oceans, locate and digest toxic materials, deliver drugs in the body or remove plaque from artery walls, the scientists say.

  “It’s impossible to know what the applications will be for any new technology, so we can really only guess,” said Joshua Bongard, a senior researcher on the team at the University of Vermont.

  The robots, which are less than 1mm long, are designed by an “evolutionary algorithm” that runs on a supercomputer. The program starts by generating random 3D configurations of 500 to 1,000 skin and heart cells.

  Each design is then tested in a virtual environment, to see, for example, how far it moves when the heart cells are set beating.

  The best performers are used to spawn more designs, which are then put through their paces.

  As heart cells spontaneously contract and relax, they behave like miniature engines that drive the robots along until their energy reserves run out. The cells have enough fuel inside them for the robots to survive for a week to 10 days before keeling over.

  The scientists waited for the computer to churn out 100 generations before picking a handful of designs to build in the lab. They used tweezers and cauterizing tools to sculpt early-stage skin and heart cells scraped from the embryos of African clawed frogs, Xenopus laevis.

  The source of the cells led the scientists to call their creations “xenobots.”

  Writing in the Proceedings of the National Academy of Sciences, the researchers describe how they set the robots loose in dishes of water to keep the frog cells alive. Some crept along in straight lines, while others looped around in circles or teamed up with others as they moved around.

  “These are very small, but ultimately the plan is to make them to scale,” Levin said.

  Sam Kriegman, a doctoral student on the team at the University of Vermont, said that the work did raise ethical issues, particularly given that future variants could have nervous systems and be selected for cognitive capability, making them more active participants in the world.

  “What’s important to me is that this is public, so we can have a discussion as a society and policymakers can decide what is the best course of action,” Kriegman said.
• Most Popular

  • 1

    Taiwanese lose status after obtaining single-use Chinese passport

  • 2

    KMT chair to meet with Xi, but at a price: source

  • 3

    Deterring Taiwan conflict a priority: US

  • 4

    Taiwanese tourists go viral in video during Japan quake

  • 5

    US vows deterrence ‘through strength’