A research team at National Taiwan University (NTU) has discovered a gene that curbs liver cancer metastasis and another that triggers coronary artery disease, the team's instructor said yesterday.
Lin Shu-hua (林淑華), a professor at the university's Department of Clinical Laboratory Sciences and Medical Biotechnology, said her research team's discovery came from experiments with the "knockout mouse" technique, which uses a mouse that has had the function of one or more of its genes deleted or made non-functional, to study the correlations of genes and diseases.
LIVER CANCER
Lin said the team's discovery would help in developing new medicine and designing clinical experiments for liver cancer and cardiovascular disease.
She said that the X gene -- one of the two genes isolated -- helps curb liver cancer metastasis. Her team implanted liver cancer cells in mice, knocked out their X genes and observed metastasis and tumor clusters on them in the experiment.
The discovery might be helpful in improving the effects of liver cancer treatment if the correlation between the disease and the gene, which Lin described as "a guard" protecting the liver, is established through further experiments, she said.
In addition, the team found that the thromboxane A2 gene, or TXA2, causes coronary artery narrowing. The team's experiment knocked out that gene from mice, fed them high cholesterol food and found the percentage of coronary artery narrowing declined.
The team performed cardiac catheterization operations on the same mice and found that blood vessel damage was rare after the operations.
Lin said patients who receive cardiovascular stent operations usually have a 50 percent risk of suffering coronary artery narrowing following the operation.
LOWER CHANCES
The discovery assumes that medicine that curbs the TXA3 gene would lower the chances of getting cardiovascular disease, Lin said.
The knockout mouse technique has the greatest potential in the field.
Three scientists were awarded the Nobel Prize for Medicine last year for producing the first knockout mice. Oliver Smithies, one of the scientists, was Lin's instructor.
NATIONAL SECURITY: Authorities are working to confirm the identities of the military personnel involved and investigating possible illegal conduct and regulatory violations Authorities are probing possible national security implications after Kinmen police and immigration officers on Sunday found a Chinese woman allegedly posing as a tourist while engaging in prostitution involving more than 10 military personnel. The woman, surnamed Chen (陳), has since been deported, authorities said, adding that investigators are still working to confirm the identities of those implicated, as the records only listed code names and aliases. The case stemmed from a report received by the Kinmen District Prosecutors’ Office on Friday last week from the Jinhu Precinct of the Kinmen County Police Bureau. On Sunday, police, along with the National Immigration
GLOBALGIVING: ‘ Caving to external pressure is not acceptable for an organization that has cultivated justice reform and human rights for 30 years,’ one NGO said A slew of non-government organizations (NGOs) have withdrawn from the GlobalGiving fundraising platform after it announced it would use “Chinese Taipei” instead of “Taiwan” from next month. The Taiwan Good Rice Association wrote on Facebook on Friday that it was informed on April 28 via a teleconference call of the change, which was made because the platform wanted to operate in China. Taiwan Good Rice is to terminate all cooperative relationships with GlobalGiving in response to the platform’s “unilateral and non-negotiable” decision to remove references to Taiwan, the NGO said. “Taiwan is in the official name of Taiwan Good Rice Association and the
HEAVY WEATHER: Typhoon Jangmi is due to crash straight into the Ryukyus as airlines look to shift flights to larger aircraft or cancel flights to Okinawa entirely Taiwan’s international air carriers announced flight adjustments over the weekend as Typhoon Jangmi is forecast to hit the Ryukyu Islands today and tomorrow. The Central Weather Administration (CWA) upgraded Jangmi from a tropical storm to a typhoon at 8am yesterday, with the eye located 580km south of Naha city. It was moving north at 19kph. Today, China Airlines’ CI-120, CI-121, CI-122 and CI-123 flights between Taoyuan and Naha, Okinawa, have been canceled as well as CI-132 and CI-133 between Kaohsiung and Naha. EVA Air’s BR-112, BR-113, BR-186 and BR-185 flights between Taoyuan and Naha are also canceled. Low-cost carrier Tigerair Taiwan canceled IT-230,
Chinese Nationalist Party (KMT) Chairwoman Cheng Li-wun (鄭麗文) yesterday briefed her party’s Central Standing Committee regarding her scheduled visit to the US between Monday next week and June 16, saying that her purpose would be to persuade the US that the Republic of China (ROC) Constitution was a “one China” constitution that would foster stable and peaceful cross-strait relations. The ROC Constitution is the most important defense for all Taiwanese citizens, as it upholds our democracy and has contributed to our robust economy, which aligns with international and US interests, she said. “We would not be troublemakers and drag the US under,”
RSS