A study in monkeys comparing the Moderna Inc COVID-19 booster against a shot specifically targeted at the Omicron variant of SARS-CoV-2 showed no significant differences in protection, suggesting that the latter might not be needed, US government researchers reported on Friday.
The study involved monkeys vaccinated with two doses of Moderna’s vaccine that were dosed nine months later with either the conventional Moderna booster or one specifically targeting the Omicron variant.
The researchers tested various aspects of the animals’ immune responses and exposed them to the virus. They found both boosters produced “comparable and significant increases in neutralizing antibody responses” against all of the variants of concern, including Omicron, according to the study posted on bioRxiv ahead of peer review.
Both Moderna and Pfizer Inc have started testing Omicron-specific boosters of their vaccines in human clinical trials.
“This is very, very good news,” said Daniel Douek, a vaccine researcher at the National Institute of Allergy and Infectious Diseases who co-led the study. “It means we don’t need to radically redesign the vaccine to make it an Omicron vaccine.”
Douek said he believes the reason is that both the original and the Omicron-specific vaccines are “cross-reactive,” meaning they can recognize many different variants.
The results are similar to studies testing a Moderna booster targeting the Beta variant, said John Moore, a professor of microbiology and immunology at Weill Cornell Medical College who was not involved in the study.
“Let’s see what the human data show,” Moore said. “Monkey data are generally pretty predictive, but you are going to need the human data.”
One key advantage of the monkey study is that researchers can boost the animals and then infect them with the virus and measure the immune response, something that could not be done in human trials, Moore said.
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