The US agency leading the fight against COVID-19 gave up a crucial surveillance tool tracking the effectiveness of vaccines just as a troublesome new variant of the virus was emerging.
While the US Centers for Disease Control and Prevention in May stopped comprehensively tracking what are known as vaccine breakthrough cases, the consequences of that choice are only now beginning to show.
At the time, the agency had identified only 10,262 cases across the US where a fully vaccinated person had tested positive for COVID-19. Most people who became infected after vaccination showed few symptoms and appeared to be at low risk of infecting others.
Illustration: Yusha
Yet in the months since, the number of vaccine breakthrough cases has grown, as has the risk that they present, and while the CDC has stopped tracking such cases, many states have not.
Bloomberg gathered data from 35 states and identified 111,748 vaccine breakthrough cases through the end of last month, more than 10 times the CDC’s tally for the end of April.
Breakthrough cases are expected, and the number and proportion of them should rise as more people are vaccinated, simply because there are more vaccinated people who could get infected. The CDC said at the time that it would continue to collect data on breakthrough cases only if the infections resulted in hospitalization or death — a rare occurrence, as vaccines provide significant protection.
The decision was made to “help maximize the quality of the data collected on cases of greatest clinical and public health importance.”
That decision is now being questioned, including by state officials dealing with the virus on the front lines.
At the same time, the CDC stopped tracking the cases, the Delta variant of SARS-CoV-2 began to spread in the US. Small numbers of Delta variant cases were identified in mid-April. The strain began to take over in some parts of the country in June, then exploded nationally last month.
It now makes up the vast majority of cases, in part because it is more contagious than prior strains. New waves of COVID-19 cases have caused a surge in hospitalizations among unvaccinated people in the south, and led US President Joe Biden’s administration and states to push for vaccine mandates.
“When I saw CDC was going to stop tracking vaccinated people who get infected, my heart sank,” said Charity Dean, who last year helped lead California’s response to COVID-19 as the California Department of Public Health’s assistant director.
Dean is now chief executive officer of the Public Health Company Group Inc, which develops and sells services to monitor and fight outbreaks.
“We lost our shot at being able to characterize how this variant is moving through the population and how new variants might emerge,” she said.
Not only is the Delta variant more contagious, health officials believe it more readily causes symptomatic — and contagious — illness in vaccinated people. That means that unlike with previous variants, vaccinated people are more likely to spread the disease more easily to unvaccinated people, or those who are vaccinated but vulnerable because of their age or health.
It is a new dynamic that punches a hole in the wall of immunity the US had been building to cordon off and stamp out the virus.
The Delta variant marked a crucial change in how the coronavirus behaved, and one with significant public health implications. Three months after the CDC stopped tracking milder breakthrough cases, the agency has reversed policy and said that even vaccinated Americans should put on masks again because of the risk that they can catch and spread the virus.
In a statement, the CDC said it continued to follow trends in breakthrough cases using studies it has set up.
The “CDC is actively tracking breakthrough cases as part of what are called cohort studies, which often involve tens of thousands of people across the country,” CDC spokeswoman Kristen Nordlund said in an e-mail. “We will continue to publish additional results from these cohort studies as they are available.”
The CDC is not without other tools to track breakthroughs and variants. It receives reports on severe breakthrough cases that result in hospitalization and death. Many states have not followed the CDC’s lead, and still tally breakthrough cases themselves.
The Atlanta-based agency is running several studies in vaccinated people to see how vaccines perform, but it has given up the ability to have near real-time numbers about what is happening on the ground, which time and time again has proven crucial in the fast-moving regional and national waves of infection.
“The more data you have, the better decisions you can make. So why would they knowingly turn away data which historically has been really important to have?” asked Michael Kinch, director of the Center for Research Innovation in Business at Washington University in St Louis, Missouri. “For an administration that said they’ll be driven by the science, it makes no scientific sense.”
Bloomberg spoke to state health officials around the US, many of whom have continued to track all vaccine breakthrough cases despite the CDC’s decision.
Many said that it was important to keep tracking breakthrough cases, especially in light of the Delta variant.
The New York State Department of Health as of July 19 had identified 11,025 vaccine breakthrough cases.
The proportion of breakthrough cases remains tiny — about 0.18 percent of vaccinated people, but New York State Department of Health spokeswoman Samantha Fuld said that following the cases is a crucial part of public health vigilance.
“Data collection, such as tracking breakthrough infections, enables us to establish a complete, accurate, and real-time view to build our understanding of disease manifestations, vaccine efficacy, and efforts to inform public health intervention,” Fuld said.
Louisiana has likewise continued to track breakthroughs. When people test positive for COVID-19, the state cross-references the tests against its vaccine registry, enabling it to identify people who were fully vaccinated but still got infected.
“Pre-Delta, it probably made less sense for the CDC to track breakthrough infections,” said Joseph Kanter, a state health officer at the Louisiana Department of Health. “Now that it’s clear that a lot of these breakthroughs are Delta, it’s more important to track that.”
New Jersey is also continuing to track the cases.
“It allows us to see if the vaccine is less effective over time, or if effectiveness is impacted by changes in virus variant,” said Edward Lifshitz, medical director of the New Jersey Department of Health’s Communicable Disease Service.
However, other states have followed the CDC’s lead and stopped.
South Carolina, Texas and Illinois all no longer track breakthrough infections unless they result in disease severe enough to hospitalize a person or result in death. The states, on their Web sites or in response to questions from reporters, said that they were following the CDC’s lead.
Nevada has also stopped tracking all but severe breakthrough infections.
Cassius Lockett, director of disease surveillance and control in the Southern Nevada Health District, said that identifying all breakthrough cases is harder work, as many people with mild or asymptomatic illness might not get tested.
However, the CDC should have considered continuing to track milder breakthrough cases, he said.
“If there was something like Delta raging through the communities at the time, if we would’ve seen evidence that Godzilla was coming, I think we would’ve had a different conversation,” he said. “We would’ve made a strong argument and pushed back on the CDC to require reports of everything.”
Bloomberg’s tally of about 100,000 state-counted breakthroughs is a tiny fraction of the 164 million people who have been fully vaccinated against COVID-19, but there is also evidence that suggests breakthrough cases can happen at a higher rate.
On Friday, the CDC released a study of COVID-19 cases in Massachusetts last month that found 274 symptomatic breakthrough cases, almost all related to the Delta variant, among people on Cape Cod.
They were infected after attending “densely packed indoor and outdoor events at venues that included bars, restaurants, guest houses and rental homes,” the CDC said — exactly the sort of socializing many vaccinated Americans are now doing.
A preliminary study showed that many of them had levels of the virus that were similar to unvaccinated people, meaning they could be just as contagious as somebody who had not been vaccinated.
Following news of the Massachusetts breakthrough cases, US Senator Edward Markey, a Democrat who represents the state, said the CDC should resume collecting data on all such cases.
In a July 22 letter to CDC Director Rochelle Walensky, he asked her why the agency had stopped doing so, and said that health officials and workers need “robust data and information to guide their decisions.”
With a better understanding of how Delta spreads, different public health measures or warnings could have been put in place for vaccinated people, said Rachael Piltch-Loeb, a Harvard T.H. Chan School of Public Health researcher on public health emergency responses.
It is hard to know if more tracking could have prevented the current cluster in Provincetown, Massachusetts, said Piltch-Loeb, but “maybe what we could have understood is that it’s not an all-clear. I think we gave the perception that there was an all-clear, and there wasn’t.”
The CDC’s studies are likely to offer updates on how the vaccines do against current and future variants, but many of the results are only as recent as March, before the Delta variant began spreading widely in the US. Much of the real-time information on COVID-19 is gathered by state and local health departments dealing with the virus.
“We’re in a war on the front lines and we need to know how Delta is moving through populations and what’s about to happen,” Dean said.
“Doing an academic study is valuable, but it’s going to take time to get that intelligence,” Dean said. “We cannot wait for certainty to act right now.”
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