National Synchrotron Radiation Research Center researchers yesterday announced the discovery of a detox mechanism of typhoid bacteria, which allows the bacteria to repel antibiotics and develop drug resistance, while the findings could help develop medicine to inhibit drug resistance.
Researchers Chen Chun-jung (陳俊榮) and Jean Yuch-cheng (簡玉成) analyzed the structure of Salmonella enterica and discovered a channel-like structure on the bacteria’s membrane protein, which could capture antibiotics and toxins inside the bacteria and remove them via the channel structure.
The channel structure is 300,000 times narrower than a human hair, Chen said, adding that the team discovered it by subjecting the protein crystals — assemblages of protein cultivated for study by X-ray or other light sources — of the bacteria to synchrotron radiation at both the Taiwan Light Source synchrotron in Hsinchu City and the SPring-8 synchrotron in Harima, Japan.
The synchrotron is a type of particle accelerator that allows for the observation of atomic structure through a sustained beam of electromagnetic waves on different wavelengths brighter than that from an X-ray tube.
Twenty-one million new cases of typhoid fever and more than 200,000 deaths occur annually worldwide and antibiotic therapy is the major treatment for typhoid fever, while it often has limited effect due to the bacteria’s ability to “pump out” antibiotics, Chen said.
The same channel structure has also been discovered on other bacteria, such as Escherichia coli and Staphylococcus aureus, which could cause serious food poisoning and post-surgery infections respectively, Chen said, adding that the team’s work could enable pharmaceutical companies to design drugs that block the channel to reduce the bacteria’s drug tolerance.
Traditional medicine development selects about 250 types of compounds from 5,000 to 10,000 kinds of small molecules for animal testing before narrowing down to less than 10 compounds for human trials, which generally take 15 years, as traditional X-ray devices take a day to analyze the atomic structure of a molecule, while the Taiwan Photon Source synchrotron in Hsinchu could lower the analysis time to 30 seconds and the entire development process to three weeks, Jean said.
“Over the past 18 years, there have been six Nobel Prizes awarded to scientists who use synchrotron in combination with protein crystallography to understand the structure of proteins. The Taiwan Photon Source synchrotron is expected to boost Taiwan’s number of Nobel Prize winners,” Jean said.
AGING: While Japan has 22 submarines, Taiwan only operates four, two of which were commissioned by the US in 1945 and 1946, and transferred to Taiwan in 1973 Taiwan would need at least 12 submarines to reach modern fleet capabilities, CSBC Corp, Taiwan chairman Chen Cheng-hung (陳政宏) said in an interview broadcast on Friday, citing a US assessment. CSBC is testing the nation’s first indigenous defense submarine, the Hai Kun (海鯤, Narwhal), which is scheduled to be delivered to the navy next month or in July. The Hai Kun has completed torpedo-firing tests and is scheduled to undergo overnight sea trials, Chen said on an SET TV military affairs program. Taiwan would require at least 12 submarines to establish a modern submarine force after assessing the nation’s operational environment and defense
A white king snake that frightened passengers and caused a stir on a Taipei MRT train on Friday evening has been claimed by its owner, who would be fined, Taipei Rapid Transit Corp (TRTC) said yesterday. A person on Threads posted that he thought he was lucky to find an empty row of seats on Friday after boarding a train on the Bannan (Blue) Line, only to spot a white snake with black stripes after sitting down. Startled, he jumped up, he wrote, describing the encounter as “terrifying.” “Taipei’s rat control plan: Release snakes on the metro,” one person wrote in reply, referring
The coast guard today said that it had disrupted "illegal" operations by a Chinese research ship in waters close to the nation and driven it away, part of what Taipei sees a provocative pattern of China's stepped up maritime activities. The coast guard said that it on Thursday last week detected the Chinese ship Tongji (同濟號), which was commissioned only last year, 29 nautical miles (54km) southeast of the southern tip of Taiwan, although just outside restricted waters. The ship was observed lowering ropes into the water, suspected to be the deployment of scientific instruments for "illegal" survey operations, and the coast
Yangmingshan National Park authorities yesterday urged visitors to respect public spaces and obey the law after a couple was caught on a camera livestream having sex at the park’s Qingtiangang (擎天崗) earlier in the day. The Shilin Police Precinct in Taipei said it has identified a suspect and his vehicle registration number, and would summon him for questioning. The case would be handled in accordance with public indecency charges, it added. The couple entered the park at about 11pm on Thursday and began fooling around by 1am yesterday, the police said, adding that the two were unaware of the park’s all-day live
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