A genetically modified cow whose milk lacks a substance that causes allergic reactions in people has been created by scientists in New Zealand.
In their first year of life, two or three in every hundred infants are allergic to a whey protein in milk called BLG, or beta-lactoglobulin protein. The researchers engineered the cow, called Daisy, to produce milk that does not contain BLG.
The genetic alteration slashed levels of BLG protein in the cow’s milk to undetectable levels.
Photo: AFP / Agresearch
The cow was created with the same cloning procedure that led to the creation of Dolly the sheep in 1996 and was delivered by caesarean at a government-owned AgResearch lab in Hamilton.
Stefan Wagner, a scientist on the team, said they now plan to investigate whether or not the BLG-free milk causes allergic reactions.
The work also drew on a technique that gives scientists control over which genes are active in an animal and gives fresh momentum to plans to engineer animals that are more resilient to diseases.
To make Daisy, scientists took a cow skin cell and genetically modified it to produce molecules that block the manufacture of BLG protein. The nucleus of this cell was then transferred into a cow egg that had its own nucleus removed.
The reconstituted egg was grown in the lab until it formed what is called a blastocyst, a ball of around 100 cells, and then transplanted into the womb of a foster cow.
The cloning technique is not efficient. Of around 100 blastocysts the scientists implanted into cows, more than half of the pregnancies failed early on, and only one live calf, Daisy, was born.
Bruce Whitelaw, professor of animal biotechnology at the Roslin Institute at Edinburgh University, said the major advance was demonstrating that the genetic procedure, called RNA interference, works in large animals.
One question the New Zealand team is working on now is why Daisy was born without a tail. The cloning process, not the extra genes, is most likely to blame.
BACKLASH: The National Party quit its decades-long partnership with the Liberal Party after their election loss to center-left Labor, which won a historic third term Australia’s National Party has split from its conservative coalition partner of more than 60 years, the Liberal Party, citing policy differences over renewable energy and after a resounding loss at a national election this month. “Its time to have a break,” Nationals leader David Littleproud told reporters yesterday. The split shows the pressure on Australia’s conservative parties after Prime Minister Anthony Albanese’s center-left Labor party won a historic second term in the May 3 election, powered by a voter backlash against US President Donald Trump’s policies. Under the long-standing partnership in state and federal politics, the Liberal and National coalition had shared power
NO EXCUSES: Marcos said his administration was acting on voters’ demands, but an academic said the move was emotionally motivated after a poor midterm showing Philippine President Ferdinand Marcos Jr yesterday sought the resignation of all his Cabinet secretaries, in a move seen as an attempt to reset the political agenda and assert his authority over the second half of his single six-year term. The order came after the president’s allies failed to win a majority of Senate seats contested in the 12 polls on Monday last week, leaving Marcos facing a divided political and legislative landscape that could thwart his attempts to have an ally succeed him in 2028. “He’s talking to the people, trying to salvage whatever political capital he has left. I think it’s
CONTROVERSY: During the performance of Israel’s entrant Yuval Raphael’s song ‘New Day Will Rise,’ loud whistles were heard and two people tried to get on stage Austria’s JJ yesterday won the Eurovision Song Contest, with his operatic song Wasted Love triumphing at the world’s biggest live music television event. After votes from national juries around Europe and viewers from across the continent and beyond, JJ gave Austria its first victory since bearded drag performer Conchita Wurst’s 2014 triumph. After the nail-biting drama as the votes were revealed running into yesterday morning, Austria finished with 436 points, ahead of Israel — whose participation drew protests — on 357 and Estonia on 356. “Thank you to you, Europe, for making my dreams come true,” 24-year-old countertenor JJ, whose
UNSCHEDULED VISIT: ‘It’s a very bulky new neighbor, but it will soon go away,’ said Johan Helberg of the 135m container ship that run aground near his house A man in Norway awoke early on Thursday to discover a huge container ship had run aground a stone’s throw from his fjord-side house — and he had slept through the commotion. For an as-yet unknown reason, the 135m NCL Salten sailed up onto shore just meters from Johan Helberg’s house in a fjord near Trondheim in central Norway. Helberg only discovered the unexpected visitor when a panicked neighbor who had rung his doorbell repeatedly to no avail gave up and called him on the phone. “The doorbell rang at a time of day when I don’t like to open,” Helberg told television
RSS