A Taiwanese infectious disease physician has expressed optimism about a new long-acting injection that, if administered twice a year, could prevent HIV infection in Taiwan.
Yang Chia-jui (楊家瑞), director of the Infection Control Center at Far Eastern Memorial Hospital in New Taipei City, on July 26 said that the long-acting injection had been proven effective during clinical trials in Africa and should also work in Asia.
The outcomes were “exciting,” Yang said, calling the innovative injection very big progress.
Photo courtesy of the Public Health Bureau
He expressed hope that the market release, expected in two years, would become a key tool in Taiwan’s HIV prevention efforts.
The latest results of the long-acting HIV jab’s third-phase clinical trial were announced at the 25th edition of the International AIDS Conference, held from July 22 to 26 in Munich, Germany.
The UN has set a goal to end AIDS by 2030, targeting zero new infections, zero deaths and zero discrimination.
Yang, who was present at the conference, said he hopes the shot would soon be available and that high-risk individuals would be willing to take it as it could help Taiwan achieve its goal of zero HIV infections.
The expert added that the injection provides a certain level of protection and that the side effects are similar to oral medications.
While oral medications have to be taken daily, the injection only needs to be administered every six months, making adherence simpler.
“This [new medication] is a significant advancement,” Yang said, adding that previous trials of oral HIV prevention in Africa failed due to difficulties in maintaining daily medication routines.
The trial in Africa involved 5,300 women, including pregnant and breastfeeding individuals, Yang said.
Trial results compared the efficacy of a long-acting injection (lenacapavir) administered twice a year with daily oral pre-exposure prophylaxis (PrEP).
The results showed that nobody who received the injection became infected with HIV.
Yang said this showed the long-acting jab was more effective at preventing HIV infections than oral medication.
Although women in Africa — in contrast to Asia — have higher infection rates than men, the jab should still to help with prevention efforts in Taiwan, he said.
While currently being used for treatment in Taiwan, the shot still needs approval for preventive use, which might take one to two years, Yang said, adding that trials including men and transgender people are ongoing overseas, with outcomes expected by early next year.
Yang said that over the past five years, Taiwan has seen a noticeable decrease in new HIV cases, primarily due to diagnosis and treatment options that reduce viral loads to undetectable levels.
However, the decreasing trend of new infections is slowing, and Taiwan needs “more effective prevention methods beyond condoms and oral medications,” he said.
The Taiwan Centers for Disease Control has provided oral PrEP for high-risk groups for several years, but adherence challenges limit its effectiveness, he added.
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