British researchers have developed a biodegradable gel to repair damage caused by a heart attack in a breakthrough that could improve the health of millions of survivors worldwide.
There are more than 100,000 hospital admissions every year due to heart attacks in the UK alone — one every five minutes. Medical advances mean more people than ever before survive, with 1.4 million Britons alive today after experiencing a heart attack. But hearts have a very limited ability to regenerate, meaning survivors are left at risk of heart failure and other health problems.
Now after years of efforts searching for solutions to help the heart repair itself, researchers at the University of Manchester have created a gel that can be injected directly into the beating heart — effectively working as a scaffold to help injected cells grow new tissue.
Photo: REUTERS
Until now, when cells have been injected into the heart to reduce the risk of heart failure, only 1 percent have stayed in place and survived. But the gel can hold them in place as they graft on to the heart.
“While it’s still early days, the potential this new technology has in helping to repair failing hearts after a heart attack is huge,” said Katharine King, who led the research backed by the British Heart Foundation (BHF). “We’re confident that this gel will be an effective option for future cell-based therapies to help the damaged heart to regenerate.
To prove the technology could work, researchers showed the gel can support growth of normal heart muscle tissue. When they added human cells reprogrammed to become heart muscle cells into the gel, they were able to grow in a dish for three weeks and the cells started to spontaneously beat.
Echocardiograms (ultrasounds of the heart) and electrocardiograms (ECGs, which measure the electrical activity of the heart) on mice confirmed the safety of the gel. To gain more knowledge, researchers will test the gel after mice have a heart attack to show they develop new muscle tissue.
The study is being presented at the British Cardiovascular Society conference in Manchester.
James Leiper, an associate medical director at the BHF, said: “We’ve come so far in our ability to treat heart attacks and today more people than ever survive. However, this also means that more people are surviving with damaged hearts and are at risk of developing heart failure.
“This new injectable technology harnesses the natural properties of peptides to potentially solve one of the problems that has hindered this type of therapy for years. If the benefits are replicated in further research and then in patients, these gels could become a significant component of future treatments to repair the damage caused by heart attacks.”
Separate research being presented at the same conference found that obesity can drive hearts to fail and weaken their structure.
The largest study of its kind on 490,000 people found that those with a higher body mass index (BMI) and waist-to-hip ratio had about a 30 percent increased risk of heart failure. This risk occurred regardless of other risks for heart failure such as diabetes, high blood pressure and high cholesterol.
Zahra Raisi-Estabragh, from Queen Mary University of London, who supervised the study, said: “We already know that obesity increases the risk of heart and circulatory diseases that can go on to cause heart failure. But now we have revealed that obesity itself could be a driver of hearts starting to fail.”
Jacques Poissant’s suffering stopped the day he asked his daughter if it would be “cowardly to ask to be helped to die.” The retired Canadian insurance adviser was 93, and “was wasting away” after a long battle with prostate cancer. “He no longer had any zest for life,” Josee Poissant said. Last year her mother made the same choice at 96 when she realized she would not be getting out of hospital. She died surrounded by her children and their partners listening to the music she loved. “She was at peace. She sang until she went to sleep.” Josee Poissant remembers it as a beautiful
March 2 to March 8 Gunfire rang out along the shore of the frontline island of Lieyu (烈嶼) on a foggy afternoon on March 7, 1987. By the time it was over, about 20 unarmed Vietnamese refugees — men, women, elderly and children — were dead. They were hastily buried, followed by decades of silence. Months later, opposition politicians and journalists tried to uncover what had happened, but conflicting accounts only deepened the confusion. One version suggested that government troops had mistakenly killed their own operatives attempting to return home from Vietnam. The military maintained that the
Before the last section of the round-the-island railway was electrified, one old blue train still chugged back and forth between Pingtung County’s Fangliao (枋寮) and Taitung (台東) stations once a day. It was so slow, was so hot (it had no air conditioning) and covered such a short distance, that the low fare still failed to attract many riders. This relic of the past was finally retired when the South Link Line was fully electrified on Dec. 23, 2020. A wave of nostalgia surrounded the termination of the Ordinary Train service, as these train carriages had been in use for decades
Lori Sepich smoked for years and sometimes skipped taking her blood pressure medicine. But she never thought she’d have a heart attack. The possibility “just wasn’t registering with me,” said the 64-year-old from Memphis, Tennessee, who suffered two of them 13 years apart. She’s far from alone. More than 60 million women in the US live with cardiovascular disease, which includes heart disease as well as stroke, heart failure and atrial fibrillation. And despite the myth that heart attacks mostly strike men, women are vulnerable too. Overall in the US, 1 in 5 women dies of cardiovascular disease each year, 37,000 of them
RSS