Australian researchers yesterday said that they have developed a blood test for melanoma in its early stages, calling it a “world first” breakthrough that could save many lives.
The scientists, from Edith Cowan University, said that the new test could assist doctors in detecting the skin cancer before it spreads throughout a person’s body.
“Patients who have their melanoma detected in its early stage have a five-year survival rate of between 90 and 99 percent,” lead researcher Pauline Zaenker said in a statement.
She added that survival rates fell to less than 50 percent if the cancer spread in the body.
“This is what makes this blood test so exciting as a potential screening tool, because it can pick up melanoma in its very early stages when it is still treatable,” Zaenker said.
The research, published in the journal Oncotarget yesterday, included a trial involving 105 patients with melanoma and 104 healthy people.
The procedure detected early stage melanoma in 79 percent of the cases, the scientists said.
Melanoma is currently detected using a visual scan by a doctor, with areas of concern cut out surgically and biopsied.
Zaenker said the new process involved identifying autoantibodies a person’s body produces in response to the cancer.
“We examined a total of 1,627 different types of antibodies to identify a combination of 10 antibodies that best indicated the presence of melanoma in confirmed patients relative to healthy volunteers,” she added.
The test would be important for high-risk groups, who have to undergo regular inspections of their spots and moles that can be difficult and time-consuming, Cancer Council Australia chief executive Sanchia Aranda said.
She cautioned that the test did not pick up other types of less deadly, but more common, skin cancers such as squamous cell and basal cell carcinoma.
“People need to be very aware of whether they’ve got sun damage or UV damage on their skin, and be alert to changes in any spots or moles,” she said.
The scientists are to conduct another clinical trial lasting three years to validate the findings and hope to have a test that clinics can use after that.
One in every three cancers diagnosed is a skin cancer, with Australia having among the highest incidences of melanoma in the world, according to the WHO.
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