This is your brain on sugar — for real. Scientists have used imaging tests to show for the first time that fructose, a sugar that saturates the US diet, can trigger brain changes that may lead to overeating.
After drinking a fructose beverage, the brain does not register the feeling of being full as it does when simple glucose is consumed, researchers found.
It is a small study and does not prove that fructose or its relative, high-fructose corn syrup, can cause obesity, but experts say it adds evidence they may play a role. These sugars often are added to processed foods and beverages, and consumption has risen dramatically since the 1970s, along with obesity. A third of US children and teens and more than two-thirds of adults are obese or overweight.
All sugars are not equal — even though they contain the same amount of calories — because they are metabolized differently in the body. Table sugar is sucrose, which is half fructose, half glucose. High-fructose corn syrup is 55 percent fructose and 45 percent glucose. Some nutrition experts say this sweetener may pose special risks, but others and the industry reject that claim.
For the study, scientists used magnetic resonance imaging (MRI) scans to track blood flow in the brain in 20 young, normal-weight people before and after they had drinks containing glucose or fructose in two sessions several weeks apart.
Scans showed that drinking glucose “turns off or suppresses the activity of areas of the brain that are critical for reward and desire for food,” said one study leader, Yale University endocrinologist Robert Sherwin.
With fructose, “we don’t see those changes,” he said. “As a result, the desire to eat continues — it isn’t turned off.”
What is convincing, Oregon Health and Science University endocrinologist Jonathan Purnell said, is that the imaging results mirrored how hungry the people said they felt, as well as what earlier studies found in animals.
Researchers now are testing obese people to see if they react the same way to fructose and glucose as the normal-weight people in this study did.
What to do? Cook more at home and limit processed foods containing fructose and high-fructose corn syrup, Purnell suggested.
“Try to avoid the sugar-sweetened beverages. It doesn’t mean you can’t ever have them,” but control their size and how often they are consumed, he said.
A second study in the journal suggests that only severe obesity carries a high death risk — and that a few extra pounds might even provide a survival advantage. However, experts say the methods are too flawed to make those claims.
The study comes from a federal researcher who drew controversy in 2005 with a report that found thin and normal-weight people had a slightly higher risk of death than those who were overweight. Many experts criticized that work, saying the researcher — Katherine Flegal of the Centers for Disease Control and Prevention — painted a misleading picture by including smokers and people with health problems ranging from cancer to heart disease. Those people tend to weigh less and therefore make pudgy people look healthy by comparison.
Flegal’s new analysis assesses nearly 100 other studies covering almost 2.9 million people around the world. She again concludes that very obese people had the highest risk of death, but that overweight people had a 6 percent lower mortality rate than thinner people. She also concludes that mildly obese people had a death risk similar to that of normal-weight people.