Kubot and Mannarino were among four players outside the top 100 who had made it to the second Monday.
However, Kubot was the only one to survive, because 166th-ranked Flavia Pennetta succumbed in straight sets to Flipkins and another Italian, 104th-ranked Karin Knapp, lost to former finalist Marion Bartoli.
Poland waited 33 years for a male Grand Slam quarter-finalist, but two arrived within minutes of each other.
The nation that boasts Radwanska as a Wimbledon finalist will have one man in the semis after Kubot set up an unlikely last-eight date with Jerzy Janowicz, who blasted down 16 aces to edge past Juergen Melzer 3-6, 7-6, 6-4, 4-6, 6-4.
Britain had also been anticipating a double celebration because for the first time since 1998, home interest was still alive in both singles draws on the second Monday.
However, hopes that US Open winner Murray and Laura Robson would both reach the last eight were dashed when the 19-year-old Robson bowed out 7-6 (8/6), 7-5 to Estonia’s Kaia Kanepi.
The road to the final opened up for Murray following the demise of Federer and Nadal, and having played the highest seed he can face before the final, No. 20 Youzhny, expectations that he will end Britain’s 77-year wait for a men’s Wimbledon champion are rocketing.
Standing in his way next is world No. 54 Fernando Verdasco.
Gentle giant Juan Martin del Potro made it through to his first Wimbledon quarter-final and is to face fourth seed David Ferrer.
Former finalist Tomas Berdych warmed up for the daunting prospect of facing Djokovic today with a 7-6 (7/4), 6-7 (5/7) 6-4, 6-4 victory over Australian Bernard Tomic.