Star Lotulelei, a native of Tonga and a defensive tackle from Utah, was taken 14th by Carolina, while German defensive end Bjoern Werner was the 24th selection by Indianapolis.
By the end, nine offensive linemen and nine defensive linemen had been taken, and just five offensive skills players.
Manuel was emotional after his surprise selection as the first quarterback taken.
“That’s something I can always tell my grandkids years from now,” he said.
Asked about those that described it as a weak draft for quarterbacks, who had been made the top overall pick the previous four years and in 12 of the last 15, Manuel said: “I think we’ll all definitely carry that chip on our shoulder.”
Rounds two and three were scheduled for yesterday, with the final four rounds today.