Brett Favre broke Dan Marino's NFL record for career touchdown passes, sparking the unbeaten Packers to a 23-16 victory over the Minnesota Vikings on Sunday.
Favre, 37, tossed his record-breaking 421st career touchdown pass on Green Bay's second possession of the game.
He hit Greg Jennings on a 16-yard cross to give the Packers a 7-0 lead with 4:56 left in the first quarter.
The 17-year veteran, who completed 32-of-45 passes for 344 yards, added to his record by tossing a 33-yard TD strike to rookie James Jones with 5:46 remaining in the fourth quarter.
"Right away it didn't hit me that it's finally over and done with," said Favre, who is already the NFL quarterback with the most all-time wins. "Maybe 30 seconds later it hit me that that's the record."
The Packers needed that score as the Vikings nearly turned a dream afternoon for Favre into a nightmare finish.
After the Vikings closed to 23-16 on Kelly Holcomb's 16-yard TD pass to Sidney Rice with 1:55 remaining, Favre fumbled after Green Bay recovered an onside kick.
Minnesota reached the Green Bay 34 before safety Atari Bigby sealed the win with an interception on a tipped pass.
"That's a big win for our football team, especially to come up here and win," Green Bay coach Mike McCarthy said. "This is a tough place to play. This is a great win for our football team and great to break [the record]."
Favre is enjoying a magical season in which he is re-writing the NFL record book and has led resurgent Green Bay to its first 4-0 start since 1998.
In addition to the career passing records, Favre also set a longevity mark. By starting his 241st consecutive game, Favre moved past Vikings center Mick Tinglehoff to top the list of consecutive starts by an offensive player.
Colts 38, Broncos 20
The reigning Super Bowl champion Indianapolis Colts improved to 4-0 by rallying from a first-half deficit to defeat the Denver Broncos 38-20.
Cowboys 35, Rams 7
In Dallas, Tony Romo passed for three touchdowns and ran for another score as the Cowboys improved their record to 4-0 with a 35-7 victory over the winless St. Louis Rams.
Browns 27, Ravens 13
In Cleveland, Jamal Lewis rushed for a touchdown against his former Baltimore Ravens team and Derek Anderson was efficient at quarterback as the Browns posted a 27-13 victory.
Falcons 26, Texans 16
The Atlanta Falcons posted their first win of the season as quarterback Joey Harrington threw two touchdown passes and Michael Jenkins found the end zone twice in a 26-16 victory over the Houston Texans.
Raiders 35, Dolphins 17
Quarterback Duante Culpepper's had a stellar return to Miami as he accounted for all five touchdowns in the Oakland Raiders' 35-17 victory over the Dolphins.
Giants 16, Eagles 3
The New York Giants used a dominant defense to defeat NFC East rivals Philadelphia 16-3.
In other NFL games on Sunday, it was:
* Cardinals 21, Steelers 14
* Bills 17, Jets 4
* Lions 37, Bears 27
* Buccaneers 20, Panthers 7
* Seahawks 23, 49ers 3
* Chiefs 30, Chargers 16
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