Ahmed Mido and Robbie Keane scored to give Tottenham a 2-0 victory at Manchester City on Wednesday as Martin Jol's team took a firm hold of fourth place in the Premier League and moved within a point of Liverpool.
It was the Hotspurs' fourth victory in five visits to Man City, and Jol's team opened up a six-point advantage over north London rival Arsenal in the race for next season's European Champions League spots.
Spurs dominated the first half hour and capitalized on a 31st-minute blunder by City defender Sylvain Distin.
The centerback tried to let a Spurs pass go out for a goalkick but misjudged the speed of the ball and Aaron Lennon dispossessed him by the line. The midfielder drew goalkeeper David James out line and laid the ball back to Egyptian striker Mido, who scored with a first-time left-foot shot.
Spurs' South Korean defender Lee Young-pyo was carried off with a leg injury in the second half after a fierce challenge by City's David Sommeil.
Spurs scored a second with three minutes to go when goalkeeper Paul Robinson's clearance was headed on by Mido, and Keane ran through to shoot powerfully past James.
Mario Regueiro and David Villa scored second-half goals and Valencia beat regional neighbor Villarreal 2-0 in a first-leg game of the fifth round in the Copa del Rey.
Both sides attacked frequently, including Villarreal, who rested Argentine captain Juan Roman Riquelme for the match.
Reguiero put Valencia ahead in the 53rd and Villa all but secured the victory 13 minutes later by converting a penalty after being pulled down by Villarreal's Argentine keeper Mariano Barbosa, who was sent off for the foul.
In other games, Deportivo La Coruna dominated second-placed Osasuna 3-0 while Celta drew 1-1 with Betis.
Elsewhere, it was: Cadiz 3, Sevilla 2 and Getafe 0, Espanyol 1. On Tuesday, it was Zamora CF 1, FC Barcelona 3 and Athletic Bilbao 0, Real Madrid 1.
Pedro Munitis put Deportivo La Coruna ahead in the 11th minute and Juan Carlos Valeron doubled the lead a minute before halftime. Argentina's Lionel Scaloni added the finale in the 85th minute.
Jesus Perera put Celta in the lead with a 22nd-minute penalty but Argentine teammate Matias Lequi allowed Betis to equalize with an own-goal in the 79th minute.
Croatian striker Nenad Mirosavljevic and Uruguayan forward Alexandre Medina scored two minutes apart to put Cadiz ahead 2-0 by the 27th minute and an own-goal by Sevilla's Ivica Dragutinovic gave Cadiz a three-goal lead by the 59th.
Malian Frederic Kanoute tried to rally Seville with goals in the 71st and 89th minutes.