The San Diego Chargers handed the New England Patriots their first loss at Gillette Stadium in 22 games on Sunday, winning 41-17 as Drew Brees threw for two touchdowns, LaDainian Tomlinson ran for two more and Antonio Gates had six catches for 108 yards.
It was the first loss in Foxborough for the Patriots since Dec. 22, 2002, when they were beaten by the New York Jets. That was the only season in the last four they failed to win the National Football League title.
Saints 19, Bills 7
In San Antonio, Aaron Brooks ran for a touchdown, John Carney kicked four field goals and New Orleans snapped a two-game losing streak in the Alamodome, its temporary home after Hurricane Katrina forced the Saints from the Superdome.
Donte' Stallworth grabbed eight receptions for 129 yards and Deuce McAllister rushed for 130 yards for the Saints (2-2).
Bengals 16, Texans 10
In Cincinnati, the Bengals improved to 4-0 for the first time since 1988 -- the last time they went to the Super Bowl -- as T.J. Houshmandzadeh caught eight passes for 105 yards.
Shayne Graham's 27-yard field goal with 5:04 left broke a 10-10 tie, and David Carr's fumble with 3:14 sent the Texans to their first 0-3 start in four seasons as an expansion team.
Cardinals 31, 49ers 14
At Mexico City, Josh McCown passed for a career-high 385 yards and two touchdowns, and Neil Rackers kicked a career-best six field goals through the 7,700-foot air in the NFL's first regular-season game outside the US.
A crowd of 103,467 -- the biggest regular-season crowd in league history -- attended the game at Azteca Stadium.
Both teams are 1-3.
Colts 31, Titans 10
In Nashville, Tennessee, Peyton Manning threw for 264 yards and four touchdowns, including two to Marvin Harrison that tied the NFL record for most TDs between a quarterback and receiver.
Harrison caught nine passes for 109 yards, and Edgerrin James also ran for 90 yards in helping the Colts improve to 4-0 with their highest point total this season.
Manning and Harrison tied Steve Young and Jerry Rice for most touchdowns between a quarterback and receiver with 85 career TDs on a 24-yard pass with 13:09 left in the game.
Redskins 20, Seahawks 17, OT
In Landover, Maryland, rookie Nick Novak kicked a 39-yard field goal 5:31 into overtime to give the Redskins their first 3-0 start since 1991, the season they won their last Super Bowl.
The Seahawks (2-2) tied the game on Darrell Jackson's 6-yard catch with 1:23 remaining. They got the ball back on Kelly Herndon's interception on a pass deflected off the outstretched fingertips of Clinton Portis, the only turnover of the game. Three plays later, Josh Brown hit the upright from 47 yards.
Broncos 20, Jaguars 7
In Jacksonville, Florida, Jake Plummer threw two touchdown passes to backup offensive lineman Dwayne Carswell, while Mike Anderson and Tatum Bell combined for 175 yards rushing.
The Broncos (3-1) won their third straight despite a short week that followed a Monday night victory against Kansas City and improved to 3-10 in Florida. They had been 0-2 in Jacksonville.
Buccaneers 17, Lions 13
In Tampa, Florida, Joey Galloway scored on an 80-yard reception and Brian Griese threw for 302 yards as Tampa Bay got off to its first 4-0 start since 1997.
Detroit (1-2) thought it would escape with a victory when Joey Harrington found Marcus Pollard in the right corner of the end zone, but the tight end's sliding catch was reversed by instant replay. Harrington hit Mike Williams on the opposite side of the end zone on the next play, but the rookie came down out of bounds. The fourth-year quarterback had one more chance but overthrew Charles Rogers on the last play of the game.
Giants 44, Rams 24
In East Rutherford, New Jersey, Eli Manning threw for 296 yards and a career-high four touchdowns in the victory.
Manning was 19-for-35 and threw for two TDs to Plaxico Burress -- who had a career-high 10 catches -- and one each to Amani Toomer and Jeremy Shockey.
Jay Feely added three field goals for New York (3-1), which entered the game having scored the most points in the NFL this season.
Eagles 37, Chiefs 31
In Kansas City, Missouri, Donovan McNabb rallied the Eagles from an 18-point deficit, completing 33 of 48 passes for 369 yards and three touchdowns as the Eagles (3-1) scored 28 straight points.
Terrell Owens helped by catching 11 passes for 171 yards and a TD. The Chiefs (2-2) closed within six points with 1:24 left on Trent Green's 15-yard TD pass to Hall, but the Eagles recovered the onside kick.
Raiders 19, Cowboys 13
In Oakland, California, LaMont Jordan ran for 126 yards and a score, Sebastian Janikowski kicked four field goals and Oakland's defense put together a late goal-line stand to secure the team's first victory.
The game wasn't decided until the final 2 minutes. Trailing 19-13 after Janikowski's 43-yard field goal with 4:29 left, Dallas (2-2) drove inside the 5.
But Tommy Kelly hit Julius Jones for a 2-yard loss on second down from the 3, and Bledsoe followed with two straight incompletions to give Oakland the ball with 1:45 to go.
Falcons 30, Vikings 10
In Atlanta, the Falcons won improved to 3-1 despite losing Michael Vick to a sprained right knee injured midway through the second quarter.
Warrick Dunn rushed for 126 yards, including his 50th career touchdown on a 37-yard run, to lead a 274-yard performance on the ground. Vick ran for 58 yards and threw a touchdown pass before getting hurt.
The Falcons' defense made things miserable for Daunte Culpepper, who was sacked nine times, intercepted twice and lost a fumble for the Vikings (1-3).
Ravens 13, Jets 3
In Baltimore, Jamal Lewis scored on a 1-yard run, Matt Stover kicked two field goals, and the Ravens won their first game of the year.
The Ravens (1-2) held Curtis Martin to 30 yards on 13 carries, sacked third-string quarterback Brooks Bollinger five times and limited the Jets (1-3) to eight first downs and 152 yards.
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