The molecule DNA is a double helix in which the strands run in opposite directions. So how better to celebrate our growing confidence in understanding the origin of life and DNA’s synthetic potential than two books in one — back to back and upside down — both called Creation, one on origins, the other on the future.
Until recently, the most widespread hypothesis on the origin of life was that originated by Darwin: “But if (& oh what a big if) we could conceive in some warm little pond with all sorts of ammonia & phosphoric salts — light, heat, electricity &c present, that a protein compound was chemically formed, ready to undergo still more complex changes.”
This became more than inspired speculation in Stanley Miller’s 1953 experiment in which electricity was passed through a mixture of common gases to produce a few of the organic chemical building blocks of life. But, as Rutherford explains, a bolt of lightning might indeed have stirred a warm pond to produce a few proto-chemicals for life, but then there would follow ... absolutely nothing. Rutherford explains why and outlines a viable alternative.
Creation: The Origin of Life is the latest attempt to popularize the theory that life evolved not in a warm pond but in the deep, cold ocean. This, originally the work of Bill Martin at the University of Dusseldorf, was elegantly outlined in Nick Lane’s prizewinning Life Ascending, and also featured in British physicist Brian Cox’s BBC series Wonders of Life.
Students are taught that the vital attributes of life can be summed up in the mnemonic “Mrs Gren:” Movement, Respiration, Sensitivity, Growth-and-repair, Reproduction, Excretion and Nutrition. But we now know that there is a crucial missing factor — one that is the key to the origin of life: constant energy. You can’t make a car go by exploding petrol in a cylinder once only. It has to keep on firing. So what were nature’s primal fuel and spark plugs? The Lost City mid-Atlantic deep-sea vents discovered in 2000 are the best bet. Here, hot, mineral-rich fluids pour into a cold ocean where a rift opens between tectonic plates. They produce mineral chimneys with porous structures in which these energy processes could have become trapped in a micro-environment shielded from the open sea.
But energy gradients in themselves are not enough. In fact, there are three things that have to come together to produce free-living life-forms: the energy cycles that now power every living organism, a container cell and a replication process. The first life, according to Rutherford, may not have been cellular at all but merely the contents of cavities in these undersea chimneys. But at some point, the cell had to appear. This is the easy part of the mystery. Cell membranes, made of lipids rather like kitchen sink detergents, self-assemble readily in the laboratory. Rutherford has a nice analogy for this kind of self-organization — he recommends observing a bowl of the breakfast cereal, Cheerios, which will spread across the surface of the milk to create a perfectly regular monolayer (although I think that mini-croutons on chicken soup illustrate the point better). Take phospholipid molecules with one water-loving end and one oil-loving and a sheet of them will automatically roll up into a hollow spherical ball, aka a cell.
But it’s replication that causes the most problems. It used to be thought of as a chicken-and-egg problem: DNA makes proteins and DNA needs protein enzymes to replicate. So how did this ever start? But the most likely answer is neither chicken nor egg but rather a chegg or an ecken. RNA is an intermediary between DNA and proteins, but it can also replicate itself with no enzymatic assistance.
In the second book, Rutherford describes the ingenuity of research in pursuit of modified life-forms. The DNA/protein system of life is universal on Earth — just four bases in DNA and 20 amino acids in proteins. But biologists are now creating novel substances: DNA analogues with additional bases or a different sugar backbone - xeno-nucleic acids or XNAs. The antiviral drug acyclovir, for example, commonly used to treat cold sores, contains a novel synthetic base that gums up the viral works.
Rutherford tells his stories with great brio and a disarming line in personal commentary (he was a lab geneticist before becoming a science writer and broadcaster). DNA is a code, a language with only four letters - A, T, C, G, for the bases Adenine, Thymine, Cytosine and Guanine — and he cleverly exploits this with telling linguistic analogies. It used to be thought — indeed Francis Crick called it the Central Dogma (for which he is correctly ticked off by Rutherford) — that DNA could only be translated into RNA, and not the reverse. Reverse transcription is big business these days, but it’s inaccurate: Rutherford used Google Translate to back translate into the home language to demonstrate the point. Using Czech, the message that “But DNA copied from RNA is riddled with errors” becomes reversed in meaning on back translation.
In fact DNA and language are rapidly converging. When, in 2010, Craig Venter created both a synthetic cell and a media storm, he inserted into the organism “watermark” messages, one being a passage from James Joyce’s Portrait of the Artist as a Young Man translated into DNA code, which made it, according to English author and journalist Charlie Brooker, “the world’s most pretentious bacterium.”
George Church, a DNA researcher at Harvard, has encoded one of his own books in DNA by translating the zero/one digital code into DNA code. Although at present it’s a lumbering process to extract the information again, the density of storage is many times higher than that of conventional computer data storage.
At fewer than 250 pages, Creation is the perfect primer on the past and future of DNA. When I began to study science it never occurred to me that, within my lifetime, we would have gone so far towards solving the eternal mysteries. Well, we have.
A few weeks ago I found myself at a Family Mart talking with the morning shift worker there, who has become my coffee guy. Both of us were in a funk over the “unseasonable” warm weather, a state of mind known as “solastalgia” — distress produced by environmental change. In fact, the weather was not that out of the ordinary in boiling Central Taiwan, and likely cooler than the temperatures we will experience in the near-future. According to the Taiwan Adaptation Platform, between 1957 and 2006, summer lengthened by 27.8 days, while winter shrunk by 29.7 days. Winter is not
Taiwan’s post-World War II architecture, “practical, cheap and temporary,” not to mention “rather forgettable.” This was a characterization recently given by Taiwan-based historian John Ross on his Formosa Files podcast. Yet the 1960s and 1970s were, in fact, the period of Taiwan’s foundational building boom, which, to a great extent, defined the look of Taiwan’s cities, determining the way denizens live today. During this period, functionalist concrete blocks and Chinese nostalgia gave way to new interpretations of modernism, large planned communities and high-rise skyscrapers. It is currently the subject of a new exhibition at the Taipei Fine Arts Museum, Modern
March 25 to March 31 A 56-year-old Wu Li Yu-ke (吳李玉哥) was straightening out her artist son’s piles of drawings when she inadvertently flipped one over, revealing the blank backside of the paper. Absent-mindedly, she picked up a pencil and recalled how she used to sketch embroidery designs for her clothing business. Without clients and budget or labor constraints to worry about, Wu Li drew freely whatever image came to her mind. With much more free time now that her son had found a job, she found herself missing her home village in China, where she
In recent years, Slovakia has been seen as a highly democratic and Western-oriented Central European country. This image was reinforced by the election of the country’s first female president in 2019, efforts to provide extensive assistance to Ukraine and the strengthening of relations with Taiwan, all of which strengthened Slovakia’s position within the European Union. However, the latest developments in the country suggest that the situation is changing rapidly. As such, the presidential elections to be held on March 23 will be an indicator of whether Slovakia remains in the Western sphere of influence or moves eastward, notably towards Russia and