Mirren, fresh from scooping the best actress award at this year's Oscars for her portrayal of Queen Elizabeth II in The Queen, will take the role of the mother of Benjamin Gates, played by Cage.
The new romp entitled National Treasure: Book of Secrets has Gates seeking to unlock the truth behind the 1865 assassination of US president Abraham Lincoln, Variety magazine said.
Other stars signed up for the Disney family flick include Ed Harris, Jon Voight and Harvey Keitel.
National Treasure, which came out in 2004, was one of the top 10 films of the year at the US box office, raking in some US$173 million, and picking up a similar amount abroad.
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