Wed, Feb 11, 2009 - Page 9 News List

More to Darwin’s theory than a ‘selfish gene’

Evolutionary theory says evolution occurs through slow changes in DNA. However, epigenetic inheritance can occur within individuals during their own lifetime and be passed on to offspring

By Eva Jablonka and Marion Lamb

ILLUSTRATION: MOUNTAIN PEOPLE

This month marks the 150th anniversary of the publication of Charles Darwin’s On the Origin of Species. The evolutionary theory he presented in that great book rests on two pillars: The idea of descent with modification and the idea of natural selection. Darwin believed that present-day organisms are descendants of much simpler ancestors, the products of unbroken lines of heredity that stretch back to the origin of life.

Today, we have a mass of evidence, ranging from studies of ancient fossils to the latest discoveries of molecular biology, that supports this theory. Darwin, however, did not invent the idea of descent with modification.

Jean-Baptiste Lamarck had suggested fifty years earlier that living things are products of a long historical process of transformation. But the evolutionary mechanisms he proposed, which included the inheritance of characteristics induced by the environment, never found favor.

It is Darwin’s second powerful idea — the idea that even the most complicated features of organisms are the outcome of natural selection — that has been the key to his theory’s long-term success. Natural selection has provided scientific explanations of traits as diverse as the mammalian eye, the bird’s wing and the ability of plants to transform light into sugars. There are now many examples of the operation of natural selection in nature.

The two pillars of evolutionary theory are the consequences of interaction among three distinctive features of living organisms: reproduction (individuals produce offspring), heredity (like gives rise to like) and variation (sometimes offspring are different from their parents).

Natural selection results whenever the differences between individuals affect the number of offspring they produce. If the variations that affect reproduction are heritable, the outcome is evolution by natural selection. Many generations of selection in a particular direction — say, for moving efficiently through the air — can give rise to complicated structures like wings and the coordinated processes of flying.

To flesh out Darwinism, we obviously have to understand the three processes that are at its core. We need to know how organisms develop and reproduce, what is inherited and how it is inherited, and how heritable variations are generated.

Until recently, biologists’ view of these processes has been very gene-centered, as exemplified by Richard Dawkins’ idea of the “selfish gene.” Inheritance and reproduction have been seen in terms of DNA and its replication and variation in terms of random changes in DNA sequences.

Yet discoveries made during the latter part of the twentieth century have shown that there is much more to inheritance than DNA. We now know of several mechanisms that enable cells with identical DNA to have different characteristics that are transmitted to daughter cells. This epigenetic inheritance is a crucial part of normal development in multi-cellular animals like us.

A person’s pancreas cells and skin cells are clearly different, yet they have the same genes with the same DNA sequences. Moreover, the cells’ features are inherited in their respective cell lineages, even though the stimuli that triggered the differences between them during embryonic development are long gone.

Epigenetic inheritance occurs not only within individuals during their development; it also occurs between generations: Individual yeast cells or bacterial cells can transmit epigenetic variations from one generation to the next, and multi-cellular organisms can transmit them through their sperm and eggs. If the epigenetic state of its germ cells is altered during an organism’s development, this variation can be transmitted to its descendants.

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