FEATURE: Breeding animals for experiments is a tricky, rewarding job, director says

Mon, Feb 14, 2022 page3

FEATURE: Breeding animals for experiments is a tricky, rewarding job, director says

QUIRKY PERSONALITIES: Some mice like to party or just raise their young, while others like to drink alcohol, which makes them ‘a lot like people,’ a lab director said
- By Kayleigh Madjar / Staff writer, with CNA
Running a facility for laboratory animals not only involves caring for thousands of mice, but also requires a sharp eye to identify each animal’s unique personality.
Whenever the conversation turns to animal personalities, National Laboratory Animal Center director-general Genie Chin’s (秦咸靜) face softens and eyes light up, like a parent excited to gush about their many children.
Apart from the independent hamster, many rodents are social creatures, she said.

Mice nibble pellets at the National Laboratory Animal Center in Taipei’s Nangang District in an undated photograph.

Photo courtesy of the National Laboratory Animal Center via CNA

For example, each of the 20,000 mice breeds has their own distinct personality traits, she said.
Some like to “party,” some are maternal and enjoy raising their young, and others even like to drink alcohol, Chin said.

“I have seen some get drunk and collapse into their feed bowl,” she said. “But others dislike alcohol and would rather die than drink.”

A mouse pokes its head out from a tiny enclosure at the National Laboratory Animal Center in Taipei’s Nangang District in an undated photograph.

Photo courtesy of the National Laboratory Animal Center via CNA

One breed Chin looked after was so sensitive that if frightened while pregnant, it would not care for its pups after giving birth.
It is therefore important not to disturb the mice during pregnancy and until the pups are grown, she said.
“I understand them better the longer I care for them,” she said. “Animals are a lot like people. Of course, I want them to be happy.”
Understanding their personalities is a key part of breeding lab animals — for instance, alcoholism research could be helped by identifying breeds that like to drink, while mice predisposed to gluttony could help with obesity research.
Personalities become apparent through observing their daily routine. If an animal’s behavior changes, it could indicate a health issue.
Wild mice enjoy foraging for materials to “decorate” their homes, so the center provides bedding made from corn husk and wood shavings to simulate natural soil, Chin said.
A healthy mouse given cotton usually rolls it into a ball and begins building a nest, but if it shows no interest, it might not be feeling well, she said, adding that they also choose the spot farthest from their nest to use as a toilet.
Rats, on the other hand, do not like to nest.
“If given a cushion, they will just plop down on it,” Chin said, laughing.
An animal lab requires many people working together to ensure that animals have enough food and water, their homes are in order and to make rounds so that a veterinarian can be called in if anything goes wrong, Chin said.
There is also a team in charge of cleaning and sterilizing items used by the animals, while researchers must regularly administer drugs to the right subjects, take samples and record results, she added.
The center has 10,000 to 20,000 cages of lab mice, meaning that a personnel shortage could have dire consequences.
During the worst part of a local COVID-19 outbreak last year, careful scheduling adjustments were needed to ensure the center stayed in working order, Chin said.
Over the Lunar New Year holiday, all cleaning had to be finished beforehand and schedules carefully planned to ensure there was no lapse in care, she added.
The center is also climate controlled, while sealed cages are equipped with their own air-conditioners with separate intake and exhaust pipes.
This means that the center is just as concerned about power outages as semiconductor fabs are, and it is equipped with multiple levels of backup for the airconditioning system.
If the emergency power supply fails to activate, the air inside the sealed cages cannot last for long, so personnel must immediately open the enclosures.
“There is life inside every cage,” Chin said. “And every life is priceless.”
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