They sound more like a Victorian freak show than science, but researchers say that glow-in-the dark monkeys created in a Japanese lab could be a breakthrough in treating human inherited diseases.
The monkeys were given a gene from a jellyfish and, significantly, it was inherited by their young — the first time a genetically modified animal has passed such genes down a generation. Researchers said it was major step towards understanding Parkinson’s and motor neurone disease.
Animal rights groups fear it could mean more primates are used in research labs. It also raises the possibility of genetically modifying humans, although such work is illegal in Britain and in most countries.
PHOTO: REUTERS
Erika Sasaki and her team at the Central Institute for Experimental Animals in Kawasaki, Japan, added a gene to marmoset embryos that made them glow green under ultraviolet light. The embryos were transferred into surrogate females, and produced five live births.
All carried the green gene somewhere in their bodies, and two passed it to offspring. Last month, a male was born using sperm from one monkey called Kou, and two more glowing marmosets have been born since. One died after being bitten by its mother. All are healthy, and do not glow under normal lighting.
The scientists plan to create families of monkeys that develop neuro-degenerative diseases.
“Our method promises to be a powerful tool for studying the mechanisms of human diseases and developing new therapies,” they wrote in the journal Nature.
But an accompanying editorial warns it “promises to raise the stakes” over animal rights by “intentionally introducing a harmful gene into the primate gene pool.”
Genetically modified mice are often used to learn about human diseases, but in some cases primates will be more informative.
“This is potentially very exciting,” said Kieran Breen of the Parkinson’s Disease Society. “Because primates are much closer to humans than mice, we’ll have a new animal model to work with.”
Aside from whether the technique can indeed recreate human-type diseases, a European directive may prohibit use of primates in such research. Vicky Robinson, of NC3Rs, which campaigns to reduce use of animals, said: “We can’t assume a transgenic marmoset will be better for disease research than, for example, a transgenic mouse. Any researcher will need to show the added scientific value of using a monkey outweighs the significant ethical considerations accompanying its use.”
Packed crowds in India celebrating their cricket team’s victory ended in a deadly stampede on Wednesday, with 11 mainly young fans crushed to death, the local state’s chief minister said. Joyous cricket fans had come out to celebrate and welcome home their heroes, Royal Challengers Bengaluru, after they beat Punjab Kings in a roller-coaster Indian Premier League (IPL) cricket final on Tuesday night. However, the euphoria of the vast crowds in the southern tech city of Bengaluru ended in disaster, with Indian Prime Minister Narendra calling it “absolutely heartrending.” Karnataka Chief Minister Siddaramaiah said most of the deceased are young, with 11 dead
By 2027, Denmark would relocate its foreign convicts to a prison in Kosovo under a 200-million-euro (US$228.6 million) agreement that has raised concerns among non-governmental organizations (NGOs) and residents, but which could serve as a model for the rest of the EU. The agreement, reached in 2022 and ratified by Kosovar lawmakers last year, provides for the reception of up to 300 foreign prisoners sentenced in Denmark. They must not have been convicted of terrorism or war crimes, or have a mental condition or terminal disease. Once their sentence is completed in Kosovan, they would be deported to their home country. In
DENIAL: Musk said that the ‘New York Times was lying their ass off,’ after it reported he used so much drugs that he developed bladder problems Elon Musk on Saturday denied a report that he used ketamine and other drugs extensively last year on the US presidential campaign trail. The New York Times on Friday reported that the billionaire adviser to US President Donald Trump used so much ketamine, a powerful anesthetic, that he developed bladder problems. The newspaper said the world’s richest person also took ecstasy and mushrooms, and traveled with a pill box last year, adding that it was not known whether Musk also took drugs while heading the so-called US Department of Government Efficiency (DOGE) after Trump took power in January. In a
LOST CONTACT: The mission carried payloads from Japan, the US and Taiwan’s National Central University, including a deep space radiation probe, ispace said Japanese company ispace said its uncrewed moon lander likely crashed onto the moon’s surface during its lunar touchdown attempt yesterday, marking another failure two years after its unsuccessful inaugural mission. Tokyo-based ispace had hoped to join US firms Intuitive Machines and Firefly Aerospace as companies that have accomplished commercial landings amid a global race for the moon, which includes state-run missions from China and India. A successful mission would have made ispace the first company outside the US to achieve a moon landing. Resilience, ispace’s second lunar lander, could not decelerate fast enough as it approached the moon, and the company has
RSS