An Academia Sinica study linking low zinc concentrations often detected in autistic people to genetic defects in two proteins suggests that autism-like behavior could be greatly ameliorated by boosting the transmission of zinc to the brain with the help of an antibiotic.
Academia Sinica research fellow and project leader Hsueh Yi-ping (薛一蘋) said her team obtained the results after performing an experiment on mice, which she said are sociable animals and therefore perfect test subjects.
Scientists compared the interactions of test mice by placing the subjects in a box, mice that had been unchanged, mice with their Tbr1 and Shank2 proteins “knocked off” and another “stranger” mouse.
Photo: Tang Chia-ling, Taipei Times
They found that unchanged mice engaged in high-level interaction with the “stranger” mouse, while mice with Tbr1 and Shank2 deficiencies interacted very little.
Hsueh’s team had previously determined that Tbr1 is a contributing factor of autism, while a team led by South Korean scientist and project coleader Eunjoon Kim discovered that Shank2 is also implicated in the condition.
Both deficiencies hamper the transmission of zinc ions to the NMDAR (N-methyl-D-aspartate) receptor, impairing function.
About 30 percent of children with autism suffer from zinc deficiency.
The researchers used clioquinol, an antibiotic used to increase zinc absorption, on the mice displaying autistic behavior and found that they began behaving in a way almost identical to that of the unchanged mice as both the level of activity and interaction with the “stranger” mouse increased, Hsueh said.
Clioquinol helps to move zinc from a presynaptic terminal to postsynaptic sites in the brain, where it undergoes a chain of chemical reactions before being picked up by the NMDAR receptor. The research teams concluded that the improvements displayed by the autistic mice were achieved with the presence of zinc.
Hsueh said that previous projects had determined that autism is linked to zinc deficiency, but the research undertaken by Academia Sinica and the South Korean researchers is the first to provide a scientific explanation for the phenomenon by establishing that the social inhibitions caused by autism can be changed by revitalizing the NMDAR receptor.
Hsueh said the results from the experiment conducted on mice can be extrapolated to humans, with a higher than 90 percent relevance between the two species.
She said that as clioquinol is a prescription drug permitted in Taiwan, her team hopes psychiatrists will prescribe the drug to suitable patients.
Citing US research, she said that autism is becoming more prevalent, with the chance of children developing the condition rising from one in every 88 children to one in every 68.
The scientific community believes that there are at least 900 genes in humans that could lead to autism, and that it is likely that the therapy can be used to target other genetic defects to improve autistic conditions, she said.
Hsueh recommends that people with autism who are diagnosed with zinc deficiency caused by the underexpression of the NMDAR receptor to increase their zinc intake by eating food high in zinc, such as oysters. She added that meat, which is rich in protein, helps boost zinc absorption.
Beijing could eventually see a full amphibious invasion of Taiwan as the only "prudent" way to bring about unification, the US Department of Defense said in a newly released annual report to Congress. The Pentagon's "Annual Report to Congress: Military and Security Developments Involving the People's Republic of China 2025," was in many ways similar to last year’s report but reorganized the analysis of the options China has to take over Taiwan. Generally, according to the report, Chinese leaders view the People's Liberation Army's (PLA) capabilities for a Taiwan campaign as improving, but they remain uncertain about its readiness to successfully seize
Taiwan is getting a day off on Christmas for the first time in 25 years. The change comes after opposition parties passed a law earlier this year to add or restore five public holidays, including Constitution Day, which falls on today, Dec. 25. The day marks the 1947 adoption of the constitution of the Republic of China, as the government in Taipei is formally known. Back then the Chinese Nationalist Party (KMT) governed China from Nanjing. When the KMT, now an opposition party in Taiwan, passed the legislation on holidays, it said that they would help “commemorate the history of national development.” That
Taiwan has overtaken South Korea this year in per capita income for the first time in 23 years, IMF data showed. Per capita income is a nation’s GDP divided by the total population, used to compare average wealth levels across countries. Taiwan also beat Japan this year on per capita income, after surpassing it for the first time last year, US magazine Newsweek reported yesterday. Across Asia, Taiwan ranked fourth for per capita income at US$37,827 this year due to sustained economic growth, the report said. In the top three spots were Singapore, Macau and Hong Kong, it said. South
Snow fell on Yushan (Jade Mountain, 玉山) yesterday morning as a continental cold air mass sent temperatures below freezing on Taiwan’s tallest peak, the Central Weather Administration (CWA) said. Snowflakes were seen on Yushan’s north peak from 6:28am to 6:38am, but they did not fully cover the ground and no accumulation was recorded, the CWA said. As of 7:42am, the lowest temperature recorded across Taiwan was minus-5.5°C at Yushan’s Fengkou observatory and minus-4.7°C at the Yushan observatory, CWA data showed. On Hehuanshan (合歡山) in Nantou County, a low of 1.3°C was recorded at 6:39pm, when ice pellets fell at Songsyue Lodge (松雪樓), a
RSS