The National Health Research Institutes (NHRI) has achieved a breakthrough in its development of an enterovirus 71 (EV-71) vaccine that can efficiently generate antibodies in humans, a member of the research team said on Tuesday.
In the first phase of the clinical trials that will be completed by the end of this year, the vaccine produced more than 600 times the normal level of antibodies in adults, said Su Ih-jen (蘇益仁), head of the National Institute of Infectious Diseases and Vaccinology.
Su said the next phase would be to test the vaccine in various age groups next year to determine how many doses are needed to resist the virus.
Phase III will be carried out at several medical centers in different countries, with the aim of finding out how much protection the vaccine can provide against EV-71 infection, he said.
The EV-71 vaccine will be considered effective if it can generate 80 to 90 percent protection, he said.
Enterovirus 71 is the most virulent strain of enterovirus. It is found in Taiwan, China and several other Asian countries.
Although Taiwan began development of an EV-71 vaccine earlier than China, Chinese researchers completed the Phase I trials before Taiwan, Su said.
The Taiwanese team has applied for seven international certificates and is optimistic about being able to offer the vaccine domestically and internationally, he said.
The NHRI has signed nonexclusive patent license agreements with Adimmune Corp and Medigen Biotechnology Corp and will transfer the technology to the two firms as the first step to entering the international market.
The institute is in partnership discussions with another biotech firm, United Biomedical.
Separately, the institute said it had also made substantial progress in the development of a vaccine against Neisseria meningitidis and would start looking for international partners by the end of this year to promote joint research and development.
As of last month, the Centers for Disease Control had confirmed three cases of severe enterovirus so far this year, all of which were EV-71 infections. One of the cases was fatal.
The nation’s first outbreak of EV-71 in 1998 killed 78 children.
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