Wed, Dec 17, 2008 - Page 2 News List

Biological mystery of ‘speciation’ gene uncovered

EVOLUTIONARY A research team discovered a gene in two similar yeasts that makes their offspring sterile, which sheds light on how speciation takes place

By Meggie Lu  /  STAFF REPORTER

Academia Sinica researcher Leu Jun-yi, center, and his students Chou Jui-yu, right, and Li Hsin-yi pose for a photograph in Taipei yesterday. Leu discovered a “speciation” gene in budding yeast, a finding that was published in the journal Cell on Friday.

PHOTO: HSIEH WEN-HUA, TAIPEI TIMES

A breakthrough has shed light on the biological mystery of why there are so many different types of species in the world after the discovery of a “speciation” gene in budding yeast by Academia Sinica (AS) researcher Leu Jun-yi (呂俊毅), the academy announced yesterday.

Leu’s finding was published in the renowned journal Cell on Friday, it added.

Speciation is the process in which one type of organism evolves — most of the time because of environmental factors — into two or more different species, Leu said, adding that a speciation gene is one that is involved in such a process.

“The question we want to ask is, why are there so many different species in the world?” he said. “Like cars of different brands, although they look alike, they function differently. For example a Porsche runs faster than a Ford, but a Ford is more energy efficient ... [Similarly] we want to know why [this occurs in different species].”

One function of speciation genes is that after organisms evolve into different species to adapt to different environments, the speciation genes make sure that the resulting different species cannot be crossbred, Leu said. In other words, the genes maintain novel adaptations during evolution, because they lose proper functions when mixed with alleles from other species.

“An example is the horse and the donkey — although they look very similar, they produce mules, which are sterile ... There are other examples where the offspring die as fertilized eggs,” he said.

Without such function, the species may lose its characteristics vital for survival, Leu said.

“For example, if a fish was crossed with a dog, the resulting offspring may be a creature that cannot function well in water or on land,” he said.

Although the speciation gene concept was discovered more than 80 years ago by famous US geneticist Theodore Dobzhansky and Hermann Muller, few speciation genes have been identified in organisms to date, Leu said.

Recently, Leu’s team discovered a gene in two similar yeasts that makes their offspring sterile, which sheds light on how the mechanism of speciation takes place.

“When crossbred, the mitochondria [the “cellular power plant” that provides energy to cells] and the nucleus [control center] of cells in the yeast do not function properly,” Leu said.

Because one yeast relies on non-fermentable carbon sources for energy, while the other depends on fermentation, the discovery also provides support for Leu’s postulation that the mitochondria in different species evolved to be different because of the ways they consume energy, he said.

Asked how his discovery could impact the field of evolutionary biology, Leu said the influence is two-fold.

“Although speciation genes have been discovered before, we can provide a clear description how this particular speciation gene functions; this is because we have a strong database documenting the functions of genes in yeasts,” he said.

Leu added that as the approach his team took was very systematic, it provides a first step to potentially discovering a universal mechanism for speciation genes.

“We want to figure out whether other yeasts also use the [mitochondria mechanism] … We have a preliminary conclusion that some of them do; [if we confirm that], this mechanism can become a universal mechanism, instead of that for a single case,” he said.

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