They sound more like a Victorian freak show than science, but researchers say that glow-in-the dark monkeys created in a Japanese lab could be a breakthrough in treating human inherited diseases.
The monkeys were given a gene from a jellyfish and, significantly, it was inherited by their young — the first time a genetically modified animal has passed such genes down a generation. Researchers said it was major step towards understanding Parkinson’s and motor neurone disease.
Animal rights groups fear it could mean more primates are used in research labs. It also raises the possibility of genetically modifying humans, although such work is illegal in Britain and in most countries.
Erika Sasaki and her team at the Central Institute for Experimental Animals in Kawasaki, Japan, added a gene to marmoset embryos that made them glow green under ultraviolet light. The embryos were transferred into surrogate females, and produced five live births.
All carried the green gene somewhere in their bodies, and two passed it to offspring. Last month, a male was born using sperm from one monkey called Kou, and two more glowing marmosets have been born since. One died after being bitten by its mother. All are healthy, and do not glow under normal lighting.
The scientists plan to create families of monkeys that develop neuro-degenerative diseases.
“Our method promises to be a powerful tool for studying the mechanisms of human diseases and developing new therapies,” they wrote in the journal Nature.
But an accompanying editorial warns it “promises to raise the stakes” over animal rights by “intentionally introducing a harmful gene into the primate gene pool.”
Genetically modified mice are often used to learn about human diseases, but in some cases primates will be more informative.
“This is potentially very exciting,” said Kieran Breen of the Parkinson’s Disease Society. “Because primates are much closer to humans than mice, we’ll have a new animal model to work with.”
Aside from whether the technique can indeed recreate human-type diseases, a European directive may prohibit use of primates in such research. Vicky Robinson, of NC3Rs, which campaigns to reduce use of animals, said: “We can’t assume a transgenic marmoset will be better for disease research than, for example, a transgenic mouse. Any researcher will need to show the added scientific value of using a monkey outweighs the significant ethical considerations accompanying its use.”
When Melinda Gates asked her husband, Microsoft Corp cofounder Bill Gates, to let her coauthor the 2013 annual letter about their foundation, the conversation blew up into a fight. “It got hot,” Melinda Gates wrote in her 2019 book The Moment of Lift. “Bill said the process we had for the Annual Letter had been working well for the foundation for years, and he didn’t see why it should change,” she wrote. Ultimately, Bill Gates agreed for her to write a separate piece about contraceptives, while he penned the main letter about the Bill & Melinda Gates Foundation’s work. In the next year’s letter,
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