Taiwanese researchers have linked higher survival rates and decreased tumor spread in patients with adenocarcinoma of the lung to a gene, the National Health Research Institute said on Friday.
This research clarifies the mechanism of lung adenocarcinoma’s spread and has implications for cancer treatment, it said.
Adenocarcinoma of the lung accounted for 40 percent to 50 percent of all cases of lung cancer, the most prevalent cause of death in Taiwan, according to government data.
Photo courtesy of the National Health Research Institute
A study led by institute associate investigator Lin Wen-jye (林文傑) discovered via bioinformatics that the expression of the DUSP22 gene is linked to better outcomes for lung adenocarcinoma patients, the institute said.
The research team drew on US-based studies on the genetic lineage of cancer cells, it said.
The DUSP22 gene encodes dual specificity protein phosphatase 22, an enzyme that plays a key role in regulating epidermal growth factor receptors (EGFR) and the downstream extracellular signal-regulated kinases pathways in lung adenocarcinoma cells, it said.
This means cancer cells lacking the gene’s expression are susceptible to tyrosine kinase inhibitors affecting the EGFR, pointing to new possibilities for targeted therapy, it said.
DUSP22 expression could potentially be applied to predict tumor severity and its responsiveness to treatments, allowing doctors to strategize treatment plans more effectively, it said.
The research could also open new doors to future studies into the role the DUSP22 gene plays in cancer cell drug resistance, microenvironment and metastasis, the institute said.
The research team’s findings deepened scientific understanding of mechanisms enabling lung adenocarcinoma progression and opened new doors to potential therapeutic approaches, it said.
The study was published in Cell Death Discovery in July last year, the institute said.
Taiwan is stepping up plans to create self-sufficient supply chains for combat drones and increase foreign orders from the US to counter China’s numerical superiority, a defense official said on Saturday. Commenting on condition of anonymity, the official said the nation’s armed forces are in agreement with US Admiral Samuel Paparo’s assessment that Taiwan’s military must be prepared to turn the nation’s waters into a “hellscape” for the Chinese People’s Liberation Army (PLA). Paparo, the commander of the US Indo-Pacific Command, reiterated the concept during a Congressional hearing in Washington on Wednesday. He first coined the term in a security conference last
Prosecutors today declined to say who was questioned regarding alleged forgery on petitions to recall Democratic Progressive Party (DPP) legislators, after Chinese-language media earlier reported that members of the Chinese Nationalist Party (KMT) Youth League were brought in for questioning. The Ministry of Justice Investigation Bureau confirmed that two people had been questioned, but did not disclose any further information about the ongoing investigation. KMT Youth League members Lee Hsiao-liang (李孝亮) and Liu Szu-yin (劉思吟) — who are leading the effort to recall DPP caucus chief executive Rosalia Wu (吳思瑤) and Legislator Wu Pei-yi (吳沛憶) — both posted on Facebook saying: “I
Sung Chien-liang (宋建樑), who led efforts to recall Democratic Progressive Party (DPP) Legislator Lee Kun-cheng (李坤城), was released on bail of NT$80,000 today amid outcry over his decision to wear a Nazi armband to questioning the night before. Sung arrived at the New Taipei District Prosecutors’ Office for questioning in a recall petition forgery case last night wearing a red armband bearing a swastika, carrying a copy of Adolf Hitler’s Mein Kampf and giving a Nazi salute. Sung left the building at 1:15am without the armband and covering the book with his coat. Lee said today that this is a serious
A mountain blaze that broke out yesterday morning in Yangmingshan National Park was put out after five hours, following multi agency efforts involving dozens of fire trucks and helicopter water drops. The fire might have been sparked by an air quality sensor operated by the National Center for High-Performance Computing, one of the national-level laboratories under the National Applied Research Laboratories, Yangmingshan National Park Headquarters said. The Taipei City Fire Department said the fire, which broke out at about 11am yesterday near the mountainous Xiaoyoukeng (小油坑) Recreation Area was extinguished at 4:32pm. It had initially dispatched 72 personnel in four command vehicles, 16
RSS