Sat, Feb 18, 2012 page2

• US BEEF CONTROVERSY: INTERVIEW: Ractopamine in beef poses health risk: toxicologist

  With the President Ma Ying-jeou administration announcing its reassessment of the viability of increasing US beef imports soon after last month’s presidential election, the first governmental inter-departmental meeting on the issue declared that “ractopamine should be differentiated from other lean meat feed additives.” The announcement caused a public uproar as it was perceived as a “sudden” departure from the common perception of Paylean as a feed additive that promotes the production of lean meat in cattle. In an interview conducted by “Liberty Times” (sister paper of the ”Taipei Times”) staff reporter Jennifer Huang, Linkou Chang Gung Memorial Hospital department of toxicology director Lin Chieh-liang said that Paylean, an additive based on ractopamine, is definitely a lean meat additive, adding that although it is less toxic than others, it could cause side-effects in humans, such as heart palpitations or cardiovascular diseases

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  Liberty Times: The Council of Agriculture (COA), after chairing the inter-departmental meeting, is alleged to have made an arbitrary statement that ractopamine-based Paylean differs from commonly known lean meat essences. Is Paylean not a kind of lean meat additive?

  Lin Chieh-liang (林杰樑): Paylean is definitely a lean meat additive. The effects of the additive are exactly the same as that of other lean-meat promoting drugs, which are to increase lean meat in cattle and pigs and to decrease the amount of excrement to lower overhead costs and maximize economic value. Nobody in the entire world would deny that fact.

  While low in toxicity in comparison with clenbuterol and salbutamol, Paylean cannot be said to be completely non-toxic. If [Paylean] is as safe as the government says it is, why is it that only 27 nations, and most of them exporters of farm animals, in the whole world dare use it? [The only explanation] is that its safety [of usage] is still doubted internationally.

  

  Lin Chieh-liang, director of the department of toxicology at Linkou Chang Gung Memorial Hospital, gestures during an interview with the Liberty Times on Feb. 10.

  Photo: Lo Pei-der, Taipei Times

  Because Paylean causes animals to grow lean meat unnaturally, it must have adverse side-effects. It is possible that it would cause palpitations or induce side-effects including cardiovascular diseases. People with cardiovascular diseases do not even have to ingest a lot of it to be poisoned; [all it takes] is for their heartbeat to accelerate to higher than 100 beats per minute — from the normal 70 to 90 beats per minute — for symptoms to begin to show, or even become fatal.

  Currently, 29 countries in the world have clear laws prohibiting the use of Paylean, while other nations, such as Singapore, do not allow the import or use of the additive. These countries have further said that they would only consider importing and using the additive if the WHO or the Codex Alimentarius Commission (Codex) has certified its safety.

  LT: Premier Sean Chen (陳冲) and other high-level officials have all been saying that no research has ever showed that anyone has been poisoned by ingesting Paylean-laced meat. It seems that [they are implying] Paylean is safe.

  Lin: The EU’s European Food Safety Authority (EFSA) released complete and in-depth scientific evaluation reports on Paylean in 2009.

  These reports were based on documents and research reports that the US offered to the WHO on the use of Paylean in the US and it also included research — which the EFSA doubted very much — cited by our government officials, saying that six subject cases did not exhibit Paylean-poisoning symptoms.

  The EFSA report said that the US’ data, with most of the statistics based on animal test subjects, had a credibility issue. It added that, for safety reasons, evaluations should also be done of human test subjects.

  The EFSA also cast doubts on the US Food and Drug Administration’s (FDA) Acceptable Daily Intake (ADI) standard of 1 microgram of Paylean per person, based on a study of six test subjects that ingested 5 milligrams of Paylean each, saying that not enough people have been tested to form a basis for setting a standard.

  The EFSA further said that of the six test subjects, one had backed out of the experiment after experiencing palpitations upon ingesting Paylean, showing the report lacked credibility.

  The EFSA also questioned why the FDA had given the test subjects a lower dosage to determine Paylean’s effects, adding that all six subjects had clean bills of health. The FDA study did not even evaluate high-risk groups with cardiovascular diseases, the EFSA said, adding that the US report would not be able to predict the safety of high-risk groups.

  Premier Chen and the COA minister kept emphasizing that there were no scientific reports of cases of Paylean poisoning. While they are certainly right, therein lies the problem — the lack of research into how Paylean affects the human body causes [public] worries.

  Besides, there are a lot of high-risk groups who face risks to their health by the side-effects of drugs that speed up heartbeat rates.

  The EU has since 2009 asked the US to provide more proof based on further tests on human subjects, especially on the epidemiology for high-risk groups, but because the US has so far not complied, the EU has kept Paylean on its prohibited list.

  LT: The governmental health organizations had already in 2007 drafted an act tolerating a certain level of residual Paylean. Would such a measure ensure the safety of people ingesting US beef?

  Lin: Neither the US’ suggestion of 1 microgram ADI, nor the Japanese standard of 10ppb (parts per billion) to 90ppb of residual Paylean in meats or intestines, correspond with the eating habits of Taiwanese.

  The Americans focus mainly on the [consumption of] meat and the Japanese do not eat intestines, but Taiwanese eat almost everything. With the concentration of residual drugs higher in the intestines — at least five to ten times the amount found in meat — the danger [posed to people] is also that much higher.

  Medical research in the past has by and large focused on the concentration of residuals in the livers and kidneys, but last year China announced research results according to which the lungs of cows also accumulate a high concentration of Paylean. This led China to tell the WHO that Paylean should be forbidden [in China], because the Chinese also eat the intestines and lungs of cows. This is the reason China forbids the importing of US beef.

  In the same vein, Taiwanese also frequently eat intestines. For example, a lactating mother, in the month after giving birth, would almost on a daily basis eat kidneys and [intestines.]

  According to an investigation by the Department of Health several years ago, pregnant women eat 360g of pig livers, 130g of pig kidneys and 92g of meat [during the month after giving birth], which would equal ingesting 27 micrograms of Paylean per day.

  While these are average rates [gleaned from] old data and [taking into account that] there are those who do not eat meat at all, some people eat a lot of meat at one sitting. Clinically, I’ve seen cases where people ate at least 600g of meat every day.

  Added to that, people now like to go to buffet-style barbeque restaurants, so it has become easy to eat too much meat and intestines every day.

  The EU also said the risk evaluation and measuring of Paylean should not only be focused on the “actual Paylean concentration,” but the concentration of its metabolic intermediates, ie, its half-metabolized products, should also be measured.

  Although the current examination does not test the metabolic intermediates like it does Paylean itself, the risk such amalgamates pose to the health of humans or animals is the same, and it should also be listed within the measurements [of potential harm to the human body].

  Besides, feed additives for most pigs and cows on the final drive to the slaughterhouse are usually left out for a certain amount of time, so they would leave no residuals.

  However, the use of Paylean is not stopped, even on the day of slaughter, and the chemical properties of Paylean are not damaged [or altered] even if the meat is cooked or boiled.

  Part two of this interview will be published tomorrow.

  Translated by Jake Chung, Staff Writer

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