Britain on Monday granted its first research license to genetically modify human embryos to a project that aims to give hope to women struggling to conceive, raising ethical concerns about “designer babies.”
The decision makes Britain one of the first countries in the world to grant this type of authorization on one of science’s new frontiers and follows months of deliberation by the British embryology regulator.
The Human Fertilisation and Embryology Authority said it had approved an application from Kathy Niakan of the Francis Crick Institute for a new laboratory research license “to include gene editing of embryos.”
Researchers explained that the embryos used would be spare ones donated by women receiving in vitro fertilization (IVF) treatment who do not need them.
Any modified embryos have to be destroyed within 14 days and cannot be implanted in a woman. The research is to examine embryos in their first few days.
“Dr Niakan’s proposed research is important for understanding how a healthy human embryo develops and will enhance our understanding of IVF success rates,” Francis Crick Institute director Paul Nurse said.
The project, which could start within months, would use CRISPR/Cas9, a technique allowing scientists to insert, remove and correct DNA within a cell.
The technique was developed by US chemistry professor Jennifer Doudna and Emmanuelle Charpentier of France and could also be used to treat illnesses like sickle cell diseases, cystic fibrosis and some cancers.
Charpentier last year said the technique was “a little bit like a Swiss knife that cuts DNA at a precise point and can be used to introduce a series of changes in the genome of a call or an organism.”
In a research paper published in April last year, Chinese scientists described how they were able to manipulate the genomes of human embryos for the first time using CRISPR/Cas9, raising ethical concerns.
Campaigners criticized Monday’s decision.
“This is the first step in a well mapped-out process leading to GM [genetically modified] babies, and a future of consumer eugenics,” watchdog group Human Genetics Alert director David King said.
A UNESCO panel of scientists, philosophers, lawyers and ministers last year called for a halt to genetic “editing,” warning of the danger of tampering with hereditary traits that could lead to eugenics.
UNESCO’s International Bioethics Committee said gene therapy could be “a watershed in the history of medicine” and genome editing “is unquestionably one of the most promising undertakings of science for the sake of all humankind.”
However, the experts warned that genetic editing required “particular precautions” and raised “serious concerns.”
There were particular grounds for concerns if the modifications “introduce hereditary modifications, which could be transmitted to future generations,” they said.
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