Scientists claim to have created human sperm for the first time, in a breakthrough they say could lead to new treatment for male infertility.
The sperm was grown in a laboratory in Newcastle, England, from embryonic stem cells. Led by professor Karim Nayernia, researchers developed a method of growing early-stage sperm from human embryonic stem cells by using retinoic acid, a vitamin A derivative.
They found that about 20 percent of the cells produced early-stage sperm cells or spermatagonia and, after further culture, they could see a number of cells continue to split and divide.
The breakthrough came when some cells continued to grow, elongating and growing a tail that caused them to move and forming recognizable sperm cells.
Nayernia, of Newcastle University and the North East England Stem Cell Institute (Nesci), described the cells as “fully mature, functional” sperm, which he called In Vitro Derived (IVD) sperm.
“This is an important development as it will allow researchers to study in detail how sperm forms and lead to a better understanding of infertility in men — why it happens and what is causing it,” he said. “This understanding could help us develop new ways to help couples suffering infertility so they can have a child which is genetically their own.”
“It will also allow scientists to study how cells involved in reproduction are affected by toxins — for example why young boys with leukemia who undergo chemotherapy can become infertile for life — and possibly lead us to a solution,” he said.
The scientist, who created mice sperm six years ago using similar techniques, said that he used four criteria to determine whether the cells he produced were sperm. They were: the presence of proteins specific to sperm, one of which is located in the tail and very important for activating egg division; chromosome analysis, which showed that the sperm produced contained 23 chromosomes, or half of the chromosome set; the shape of the sperm, which has a tail and a head; and finally the movement of the sperm.
“We could clearly see the movement of the sperm using the tail,” he said.
But his findings, published in the journal Stem Cells and Development, were met by a barrage of criticism by other scientists, who said further research was needed to determine the authenticity of his claims.
Allan Pacey of the University of Sheffield, England, said: “As a sperm biologist of 20 years’ experience, I am unconvinced from the data presented in this paper that the cells ... produced by Nayernia’s group can be accurately called ‘spermatozoa.’”
After watching a video clip of the cells, he said that while they possessed “some of the distinctive genetic features and molecular markers seen in sperm,” there were other characteristics of human sperm that were not described in the paper, while the footage “did not have sufficient resolution” for him to properly assess how the sperm was moving, another indicative factor of sperm behavior.
HISTORIC: After the arrest of Kim Keon-hee on financial and political funding charges, the country has for the first time a former president and former first lady behind bars South Korean prosecutors yesterday raided the headquarters of the former party of jailed former South Korean president Yoon Suk-yeol to gather evidence in an election meddling case against his wife, a day after she was arrested on corruption and other charges. Former first lady Kim Keon-hee was arrested late on Tuesday on a range of charges including stock manipulation and corruption, prosecutors said. Her arrest came hours after the Seoul Central District Court reviewed prosecutors’ request for an arrest warrant against the 52-year-old. The court granted the warrant, citing the risk of tampering with evidence, after prosecutors submitted an 848-page opinion laying out
STAGNATION: Once a bastion of leftist politics, the Aymara stronghold of El Alto is showing signs of shifting right ahead of the presidential election A giant cruise ship dominates the skyline in the city of El Alto in landlocked Bolivia, a symbol of the transformation of an indigenous bastion keenly fought over in tomorrow’s presidential election. The “Titanic,” as the tallest building in the city is known, serves as the latest in a collection of uber-flamboyant neo-Andean “cholets” — a mix of chalet and “chola” or Indigenous woman — built by Bolivia’s Aymara bourgeoisie over the past two decades. Victor Choque Flores, a self-made 46-year-old businessman, forked out millions of US dollars for his “ship in a sea of bricks,” as he calls his futuristic 12-story
FORUM: The Solomon Islands’ move to bar Taiwan, the US and others from the Pacific Islands Forum has sparked criticism that Beijing’s influence was behind the decision Tuvaluan Prime Minister Feletei Teo said his country might pull out of the region’s top political meeting next month, after host nation Solomon Islands moved to block all external partners — including China, the US and Taiwan — from attending. The Pacific Islands Forum (PIF) leaders’ meeting is to be held in Honiara in September. On Thursday last week, Solomon Islands Prime Minister Jeremiah Manele told parliament that no dialogue partners would be invited to the annual gathering. Countries outside the Pacific, known as “dialogue partners,” have attended the forum since 1989, to work with Pacific leaders and contribute to discussions around
END OF AN ERA: The vote brings the curtain down on 20 years of socialist rule, which began in 2005 when Evo Morales, an indigenous coca farmer, was elected president A center-right senator and a right-wing former president are to advance to a run-off for Bolivia’s presidency after the first round of elections on Sunday, marking the end of two decades of leftist rule, preliminary official results showed. Bolivian Senator Rodrigo Paz was the surprise front-runner, with 32.15 percent of the vote cast in an election dominated by a deep economic crisis, results published by the electoral commission showed. He was followed by former Bolivian president Jorge “Tuto” Quiroga in second with 26.87 percent, according to results based on 92 percent of votes cast. Millionaire businessman Samuel Doria Medina, who had been tipped
RSS