Scientists in the field of human fertility are coming under pressure to rein in maverick researchers whose experiments push ethical boundaries and caused public revulsion this week.
Critics say the lack of agreed standards is damaging the reputation of more mainstream researchers. While some countries have stringent guidelines backed up by enforceable legislation, others have none at all.
In those cases, given the will and the cash, anything goes. Eggs and sperm, donated in good faith, can be used in whatever research the scientists desire. Paul Serhal, director of the assisted conception unit at University College London, said fertility research was facing a critical question: "How do we prevent people doing monstrous things?"
The ethical crisis was thrown into vivid relief this week at a European fertility conference in Madrid when an Israeli-Dutch team reported they had matured eggs from an aborted foetus in the hope of finding a new source of eggs for couples needing treatment. Alarmed headlines were followed the next day with the news that a private fertility clinic in America had created bizarre hybrid human embryos called chimeras by merging male cells with female embryos.
Neither experiment would have been allowed in the UK, says the human fertility and embryology authority (HFEA). But the hybrid embryos had received ethical approval in the US and the foetal eggs research was approved in Israel. Both studies were presented in Madrid at the European Society of Human Reproduction and Embryology's annual meeting.
Most scientists are in no doubt that the studies, in particular the work on chimeric embryos, have delivered a blow to the public's confidence in fertility research.
"Studies of this nature are going to backfire on mainstream scientists who are doing genuine scientific work," said Serhal. "They will tarnish our image."
Only the HFEA can issue licenses for research on embryos in the UK. Certain areas are banned, such as placing a human embryo in an animal. The authority would not have approved the chimera work. "We think it's illegal," said Alison Cook of the HFEA. "The [HFEA] Act says that we are not allowed to alter the genetic material of any embryonic cell. We believe the spirit of the law would not allow you to put in an extra cell."
The prospect of a child being born from an egg from an aborted foetus would also be unacceptable to the authority because of the difficulty for the child coming to terms with its origins. All IVF (in vitro fertilization) clinics must consider above all the interests of the children they may help create. But the framework in the UK is not mirrored elsewhere.
"The country you most need to regulate is the one that's least likely to accept regulation -- the United States," said fertility expert Robert Winston at Hammersmith hospital, west London. "The problem is that they do not in general want central regulation, so you have different rules in different states."
Federal law washes its hands of embryo research by a refusal to fund any of it, so the work is left to private clinics and research institutes governed by the patchwork of state laws. A few states ban embryo research because of the passions evoked over abortion and the right to life. Elsewhere there is little restraint.
Norbert Gleicher, whose team created the chimera foetuses, is the founder and head of the for Human Reproduction, which has clinics in Chicago and New York. He appeared to have no trouble getting ethical approval for the work, which was intended to investigate a technique for curing genetic diseases.
Scientists are divided on how best to tackle the maverick element of fertility researchers or whether they even need to be tackled.
"The only way to rein them in is to have a body like the HFEA in different countries," said Serhal. "When you know there is someone breathing down your neck, you're going to think twice, if not more, before doing something stupid."
But there is no guarantee a global HFEA would be the answer. In the UK, some private clinics flout the fertility guidelines but do not seem to be penalized.
"They aren't even being threatened with having their licenses taken away," said Allan Templeton of the Royal College of Obstetricians and Gynecologists.
Le Tuan Binh keeps his Moroccan soldier father’s tombstone at his village home north of Hanoi, a treasured reminder of a man whose community in Vietnam has been largely forgotten. Mzid Ben Ali, or “Mohammed” as Binh calls him, was one of tens of thousands of North Africans who served in the French army as it battled to maintain its colonial rule of Indochina. He fought for France against the Viet Minh independence movement in the 1950s, before leaving the military — as either a defector or a captive — and making a life for himself in Vietnam. “It’s very emotional for me,”
Indian Prime Minister Narendra Modi reaffirmed his pledge to replace India’s religion-based marriage and inheritance laws with a uniform civil code if he returns to office for a third term, a move that some minority groups have opposed. In an interview with the Times of India listing his agenda, Modi said his government would push for making the code a reality. “It is clear that separate laws for communities are detrimental to the health of society,” he said in the interview published yesterday. “We cannot be a nation where one community is progressing with the support of the Constitution while the other
The Chinese Communist Party’s (CCP) Central Committee is to gather in July for a key meeting known as a plenum, the third since the body of elite decisionmakers was elected in 2022, focusing on reforms amid “challenges” at home and complexities broad. Plenums are important events on China’s political calendar that require the attendance of all of the Central Committee, comprising 205 members and 171 alternate members with Chinese President Xi Jinping (習近平) at the helm. The Central Committee typically holds seven plenums between party congresses, which are held once every five years. The current central committee members were elected at the
CODIFYING DISCRIMINATION: Transgender people would be sentenced to three years in prison, while same-sex relations could land a person in jail for more than a decade Iraq’s parliament on Saturday passed a bill criminalizing same-sex relations, which would receive a sentence of up to 15 years in prison, in a move rights groups condemned as an “attack on human rights.” Transgender people would be sentenced to three years’ jail under the amendments to a 1988 anti-prostitution law, which were adopted during a session attended by 170 of 329 lawmakers. A previous draft had proposed capital punishment for same-sex relations, in what campaigners had called a “dangerous” escalation. The new amendments enable courts to sentence people engaging in same-sex relations to 10 to 15 years in prison, according to the