Ryan Fitzpatrick tossed a 10-yard touchdown pass to Kendall Wright with 10 seconds remaining to give the Tennessee Titans a 23-19 victory over the Oakland Raiders, while Ben Roethlisberger completed 22 of 34 passes for 217 yards to spark the Pittsburgh Steelers over the Cleveland Browns 27-11.
Joe Flacco threw a 66-yard touchdown pass to Jacoby Jones and Justin Tucker kicked four field goals to lift reigning Super Bowl champions the Baltimore Ravens over the visiting New York Jets 19-3.
Benny Cunningham, Zac Stacy and Tavon Austin each ran for touchdowns as hosts the St Louis Rams routed the Chicago Bears 42-21.
Leonard Johnson returned one of four Tampa Bay interceptions for a touchdown as the Buccaneers edged hosts the Detroit Lions 24-21, while the Green Bay Packers and the Minnesota Vikings played to a 26-26 draw.
Carson Palmer threw two touchdown passes to Larry Fitzgerald to spark the Arizona Cardinals over the Indianapolis Colts 40-11, while Maurice Jones-Drew ran for 84 yards and a touchdown to boost the visiting Jacksonville Jaguars past the Houston Texans 13-6.