United also lost in the Champions League in mid-week, going down 1-0 at home to Romanian champions CFR Cluj, but their progress to the last 16 was already assured.
United midfielder Tom Cleverley will undergo a scan on a calf injury to find out if he will be fit to play, but wingers Antonio Valencia and Nani are both out as is midfielder Anderson.
Nemanja Vidic and Shinji Kagawa are rated as doubtful.
Mancini hopes to be able to recall Spanish midfielder David Silva after a hamstring injury.
James Milner and Gael Clichy could also be in contention, but Aleksandar Kolarov has been ruled out with an ankle problem.