In Toronto, Vernon Wells had four RBIs as Toronto thrashed New York 15-4.
Blue Jays starter Roy Halladay (13-5) struck out eight over seven innings.
Toronto has won nine of their past 11 home games and matched a franchise record with nine doubles.
Robinson Cano hit two home runs but the Yankees' five-game winning streak came to a close.
New York's Wang Chien-ming (13-6) allowed a career-high eight runs over two 2-3 innings, his shortest career outing.
Red Sox 9, Angels 6
Rookie Dustin Pedroia hit a tiebreaking home run to give Boston a 9-6 win over Los Angeles on Wednesday to prevent a three-game sweep.
Mike Lowell went four-for-four with three doubles for the Red Sox, who increased their lead over New York in the American League East to six games.
The Angels' lead over Seattle in the American League West shrunk to three games.
Pedroia's home run off Justin Speier (1-3) glanced off left fielder Garret Anderson's glove and went over the fence to give Boston a 7-6 lead in the seventh inning, and they tacked on two more runs in the eighth.
Hideki Okajima (3-0) pitched one 1-3 hitless innings for the victory. Jonathan Papelbon pitched a perfect ninth for his 26th save.
Devil Rays 7, Tigers 1
In Detroit, Dioner Navarro had three hits, including a two-run homer, and Tampa Bay snapped an eight-game road losing streak with a 7-1 victory over Detroit on Wednesday.
Navarro, who also homered on Tuesday, is now hitting above .200 for the first time since May.
The Tigers, who are 3-10 from its past 13, remain half a game behind first placed Cleveland in the American League Central.
Devil Ray's starter James Shields (9-7) gave up just one run in seven innings.
Detroit starter Chad Durbin (7-5), making his first start since June 19, allowed six hits in four 1-3 innings.
Wednesday's other American League results:
* Mariners 8, Orioles 4
* Twins 11, Royals 4
* Athletics 6, Rangers 3
* White Sox 6, Indians 4
Barry Bonds hit home run No. 757 and San Francisco manager Bruce Bochy picked up victory No. 1,000 with the Giants' 5-0 win over Washington on Wednesday.
Bonds hit a two-run homer in the first inning, one night after breaking Hank Aaron's 33-year-old record with his 756th.
San Francisco starter Matt Cain (4-12) hit his first career home run in his 112th at-bat and allowed three hits in six innings. Jack Taschner pitched two innings and Vinnie Chulk finished the four-hitter for the team's eighth shutout this season. The Nationals were blanked for the ninth time.
Bochy became the 55th skipper in major league history to reach the 1,000 win mark. He is sixth among active managers.
Washington's Tim Redding (1-3) allowed four runs in seven innings.
Mets 4, Braves 3
In New York, Moises Alou hit a tiebreaking homer in the eighth inning to lead New York to a vital 4-3 win over Atlanta.
Mets closer Billy Wagner escaped a bases-loaded, no-out jam in the ninth as New York clung on to extend its lead over the Braves in the National League East to four 1-2 games.
Wagner earned his 350th career save -- 26th this season -- and extended his scoreless streak to 21 innings when Andruw Jones grounded into a game-ending double play. Jeff Francouer bounced into a force play at the plate for the first out.
Shawn Green went four-for-four for the Mets, who levelled scores in the seventh before Alou homered off Rafael Soriano (2-3).