Sosa lined a solo shot off the front row of the Monster Seats to break a 4-4 tie.
Indians 8, Devil Rays 6
At Cleveland, C.C. Sabathia became the majors' first 12-game winner and Grady Sizemore drove in three runs to lead Cleveland over Tampa Bay.
Sabathia (12-2) matched last season's win total and is 7-1 with a 2.62 ERA in his past 10 starts.
Orioles 6, Angels 3
At Baltimore, Brian Burres gave up just three hits entering the eighth inning, Ramon Hernandez hit a three-run homer and the Orioles improved to 6-4 under interim manager Dave Trembley by beating Los Angeles.
Kevin Millar drove in two runs and scored twice and Melvin Mora recorded straight three-hit games for the Orioles.
White Sox 3, Royals 1
At Kansas City, Tadahito Iguchi poked a two-run single into right field with two out in the 10th inning, helping Chicago snap Kansas City's five-game win streak.
Octavio Dotel (0-1) started the 10th. He gave up a pinch single to A.J. Pierzynski, then hit Scott Podsednik, who reached base for the fourth time in the game.
Mariners 8, Blue Jays 3
At Seattle, Miguel Batista pitched into the seventh inning and Ben Broussard tied a career-high with four hits as Seattle won its seventh straight game by downing Toronto.
It's Seattle longest win streak since it took nine in a row in 2003.
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