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Sun, Nov 20, 2005 - Page 12 News List

Roche tries to protect its golden ticket and meet rampant demand

With fears about bird flu on the rise, Tamiflu is a potential gold mine, but Roche says it will do everything necessary to ensure governments around the world can have access to the drug


An undated company handout photograph from Swiss pharmaceutical concern Roche Products shows a worker supervising the packaging of Tamifu, the drug that combats the effects of bird flu in humans. Photo: EPA

Swiss drugmaker Roche has found itself sitting on a gold mine with its Tamiflu antiviral drug in hot demand around the world because experts are pinning their hopes on it as the best defense against an influenza pandemic.

But the attention has put pressure on the company to step up production, cut prices and allow other companies to make copies of Tamiflu. Critics have questioned the company's intentions. Governments and individuals, fearing that the current bird flu virus could mutate into a strain that easily transmits among humans, have been snapping up supplies.

Roche, whose control of Tamiflu has been the subject of debate for weeks, opened its headquarters in Basel to reporters on Wednesday for a full-day tour and demonstration of the drug's manufacture -- which the company maintains is extremely complicated.

Top executives first briefed a packed amphitheater of reporters and then sent them on a three-hour tour of its plants, past swirling beakers, giant fermentation vats and filters.

The executives reiterated several times their philosophy that "the patient comes first" and sought to reassure governments concerned about bird flu, saying the company was producing enough of its antiviral drug Tamiflu to treat 55 million people this year.

David Reddy, the company's influenza pandemic task force leader, said production will be nearly tripled next year to 150 million treatments, and that in 2007, Roche will be in a position to make 300 million treatments.

In the same breath, executives played down the current threat of a pandemic and Tamiflu's role in the case it happened.

"At the moment it's an animal welfare and economic problem," said William Burns, chief executive of the pharmaceutical division, in an apparent reference of the slaughter of more than 150 million chickens and other poultry at farms primarily in Asia. "We need to keep a sense of balance and a sense of proportion."

"Pandemic preparedness is Tamiflu and more. The preparedness of society will need to be much greater. How are we going to keep the wheels of society turning? There won't be enough intensive care units or respiratory equipment," he said.

But John Oxford, a professor of virology at Queen Mary's University of London, who said he would receive a fee for speaking at the Roche briefing, insisted much of the burden rested with Tamiflu.

"We need plans and ammunition and Tamiflu is at least half of our ammunition," Oxford said, adding there was a clear relationship between the current H5N1 strain and the deadly Spanish flu virus of 1918-1919. "Without Tamiflu, we would be going into this naked."

He also warned that bird flu was "like the Scarlet Pimpernel: You never know where it's going to appear. And it's got a greater spectrum of variety than any other flu virus we've ever seen before."

Until last month, Roche had insisted it would not allow anyone else to make Tamiflu as sales of the once-obscure drug's sales have skyrocketed from US$76 million in 2001 to an expected US$1.1 billion to US$1.2 billion this year.

Consequently, Roche been accused of benefiting from a global health crisis, and has come under international pressure to ease its control on the manufacture of the drug.

The company was compared negatively to Bayer AG, the maker of anthrax treatment Cipro. In late 2001, as governments scrambled to stockpile Cipro in the face of US anthrax attacks, Bayer initially refused to disclose its production capacity or enter into reimbursement negotiations.

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