New research shows how dangerous the novel coronavirus is for current and former cancer patients: Those who developed COVID-19 were much more likely to die within a month than people without cancer who got it, two studies found.
They are the largest reports on people with both diseases in the US, the UK, Spain and Canada.
In one study, half of 928 current and former cancer patients with COVID-19 were hospitalized and 13 percent died.
That was far more than the various rates that have been reported in the general population.
The results were published on Thursday in the journal Lancet and would be discussed this weekend at an American Society of Clinical Oncology conference being held online because of the COVID-19 pandemic.
A second study in the Lancet from researchers in England of 800 patients with various types of cancer and COVID-19 found an even higher death rate — 28 percent. The risk rose with age and other health problems, such as high blood pressure.
The studies have big implications: More than 1.6 million new cancers are diagnosed in the US each year, several million Americans are in treatment now and about 20 million are cancer survivors.
Jeremy Warner, a Vanderbilt University data scientist who led the larger study, said that the results show the wisdom of measures that many hospitals have taken to delay or modify care for many cancer patients, and the need for people treated in the past to be extra careful now.
“If they don’t have COVID-19, they want to do anything they can to avoid getting it,” Warner said.
“The pandemic is posing incredible demands on the cancer care system” and the new studies show good reason for concern, said society president Howard Burris, who heads the Sarah Cannon Research Institute in Nashville, Tennessee.
“We’re trying to minimize trips to the clinic” and telling older cancer patients and those with lung problems “to be extra vigilant, extra isolated, to stay at home, be careful with family members,” Burris said.
Nearly half of the patients in Warner’s study were receiving cancer treatment when diagnosed with COVID-19. The others either completed treatment, had not started it, been under observation or had cancer in the past.
Researchers included all of these groups because some cancer treatments can affect the lungs or immune system years later and affect the odds of surviving COVID-19, Warner said.
Men seemed to fare worse — 17 percent of them died versus 9 percent of women. That might be because breast cancer was the most common tumor type in this group, and women with it tend to be younger and with fewer health problems versus many cancers seen in men that are typically diagnosed at later ages. Smoking was also more common among men.
The risk of death also seemed higher for patients taking the malaria drug hydroxychloroquine in addition to the antibiotic azithromycin, but this could be because sicker patients were given those drugs.
Of the 928 study participants, 89 took hydroxychloroquine and 181 took the combination.
The rate of death in patients getting both drugs was 25 percent, about double the 13 percent for the group as a whole, Warner said.
“We do not know if this is cause and effect,” and studies like this cannot prove such a link, he said.
Use of hydroxychloroquine alone was not tied to a significantly higher risk of death, but there were fewer patients taking it this way.
Unless cancer patients are in one of the carefully designed studies that are testing hydroxychloroquine now, “don’t take that drug” on your own, Warner said.
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