The National Health Research Institutes (NHRI) yesterday said that tests of its DNA vaccine against COVID-19 on hamsters was promising, with clinical trials likely to start later this year.
The institute on July 1 chose the DNA vaccine among its four vaccine development platforms as its main focus and started animal testing, Institute of Infectious Diseases and Vaccinology director Liao Ching-len (廖經倫) said.
“The vaccine has shown the effect of significantly reducing the viral load and decreasing the damage that the virus caused to the lungs” of hamsters, he said.
Photo: Wu Liang-yi, Taipei Times
“With the DNA vaccine, we deliver genetic information [a plasmid containing the DNA sequence encoding the antigens against COVID-19] into the human body, and when it enters the cells, the cells produce spike proteins,” Liao said.
He said it is similar to the actual situation of when someone is infected by the virus, stimulating the body’s immune response.
In animal testing, the vaccine successfully stimulated the production of neutralizing antibodies, blocking the viral infection, he said.
Hamsters that did not receive the vaccine lost weight and general vitality, and their viral load remained high, while those that received the vaccine did not lose much weight or vitality and their viral load dropped significantly to 1 percent of the original volume, Liao said.
He said the research team was “amazed” at the results of animal testing.
“We hope the experiments can proceed to the first phase of a clinical trial in the fourth quarter this year, finish the third phase of the clinical trial by the third quarter next year, and hit the market as soon as possible,” he said.
FATAL FIRE: The health department is trying to contact the inspector who visited the site of the illegal nursing home to ask why they did not advise follow-up checks The Taipei City Government yesterday said that a health department inspector last year had visited the site of a long-term care facility in Neihu District (內湖) after receiving a report questioning its status. A fire broke out at the facility on Tuesday afternoon, killing three people. The Taipei Fire Department said that it received a report about a fire on the first floor of a four-story residential building on Kangning Road Sec. 1 at 2:38pm on Tuesday, firefighters arrived at 2:43pm and the fire was put out by 3:07pm. The firefighters found three men in beds and rushed them to hospital for
Taipei City Councilor Wang Hao (王浩) of the Chinese Nationalist Party (KMT) on Monday called for security improvements to the MRT, as fare evasion has increased more than 13-fold on the metropolitan railway system over the past five years. Taipei Mayor Ko Wen-je (柯文哲) has spoken out against fare evasion and other contraventions of MRT regulations, but since he took office in 2015 the number of contraventions has more than doubled, Wang said, adding that there were 537 cases in 2015 compared with 959 last year. A video was posted to YouTube in June showing people how to evade paying a fare,
THE CHINA CONNECTION: As Beijing’s aggression increases, so does Taiwanese consciousness, making a new constitution imperative, Hsu Wei-chun said If the nation is to ratify a new constitution, it must first end any illusions about the current document’s relevance to Taiwan, an academic told a forum in Taipei yesterday. For the constitutional revisionist movement to succeed, it needs public enthusiasm, the right timing and a clear plan of action, Chung Yuan Christian University associate professor Hsu Wei-chun (徐偉群) told attendees at the event titled “Imagining a New Constitution for a New Era,” which was organized by the National Taiwan University Graduate Student Association. The Constitution exists under the “one China” framework and has little relevance to Taiwan, Hsu said, adding that
Yuchi Township (魚池) fishers have appealed to the Nantou County Government for help in dealing with an invasive fish species in Sun Moon Lake (日月潭), where it has devastated the local ecosystem. Fishers at Sun Moon Lake have been using electrofishing in an attempt to eliminate the giant snakehead fish — found in Africa and Southeast Asia — but they have struggled to keep up with the growing population of the species, which breeds during September and October, the county government said on Monday. The county has contacted researchers at National Tsing Hua University, saying it hoped they could come up
RSS