Lleyton Hewitt of Australia was upset in the second round of the Canada Masters, losing 7-5, 6-7 (4), 7-5 to Max Mirnyi Belarus on Wednesday.
Hewitt has lost four of his last nine matches, including a first-round exit as the defending champion at Wimbledon. His ranking has dropped to No. 5 in the world.
Those reaching the third round included Americans Andre Agassi and Andy Roddick, Wimbledon champion Roger Federer of Switzerland and French Open winner Juan Carlos Ferrero of Spain.
Andre Agassi waited through a 90-minute rain delay, then made quick work of Russia's Nikolay Davydenko 7-6 (3), 6-2 Wednesday to reach the third round of the Canada Masters.
The top-seeded Agassi is trying for his fourth title at this hard-court tuneup for the US Open, which starts Aug. 25.
His next opponent will be Simon Larose of Canada, who beat Argentina's Jose Acususo 7-6 (5), 1-6, 7-5.
"This is something I dreamed about when I was 12 or 13, and I watched him play when he had long hair," Larose said, referring to Agassi. "I remember saying: `One day, I'll play against him.' Now, that day is here."
Larose, who's ranked 314th, upset three-time French Open champion Gustavo Kuerten of Brazil in the first round.
In other action, Roddick topped Argentina's Juan Ignacio Chela 7-6 (6), 6-2, Federer beat Britain's Greg Rusedski 6-4, 6-3, Ferrero defeated Morocco's Younes el Aynaoui 6-3, 6-4 and 2002 Wimbledon runner-up David Nalbandian of Argentina ousted Britain's Tim Henman 6-4, 6-4.
America's Vince Spadea eliminated Frenchman Arnaud Clement 6-0, 6-7 (5), 7-5 and Thailand's Paradorn Srichaphan ousted Daniel Nestor of Canada 7-5, 6-4. Federer's next opponent will be 16th-seeded Spaniard Tommy Robredo, who defeated Zimbabwe's Wayne Black 6-0, 6-2.
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