Tue, Jul 23, 2013 - Page 7 News List

Embryonic stem cells could help treat blindness

The Guardian, LONDON

Scientists have shown that light-sensitive retinal cells, grown in the lab from stem cells, can successfully integrate into the eye when implanted into blind mice. The technique opens up the possibility that a similar treatment could help people who have become blind through damage to their retinas to regain some sight.

Loss of light-sensitive nerve cells, known as photoreceptors, is a significant cause of blindness in conditions such as age-related macular degeneration, retinitis pigmentosa and diabetes-related blindness. These conditions affect many thousands of people in the UK alone and there is no effective treatment at present. Scientists have been exploring the possibility of somehow replacing the photoreceptors, which come in two types: rods, which help us see in low light conditions, and cones, which help us differentiate colors.

Robin Ali at the University College London’s (UCL) Institute of Ophthalmology and Moorfields eye hospital has shown transplanting immature rod cells from the retinas of very young mice can restore vision in adult mice. It was a neat proof of concept, but the technique as it stood would be impractical as a way to treat people.

His latest work got around the problems of sourcing donor photoreceptor cells by growing and differentiating them from embryonic stem cells in a culture dish, rather than taking the cells from young mice. The donor photoreceptors developed normally once inside the adult mouse eyes and, crucially, formed nerve connections with the brain. The results were published on Saturday in the journal Nature Biotechnology.

It will be at least five years before the technique is ready for human trials, Ali said, but he is confident that this will happen.

“Now that we have proved the proof-of-concept, the road is clear to the first set of clinical trials just to see whether it’ll work,” he said. “It certainly isn’t a case of rolling out treatments in five years’ time and providing therapies. It’s taken us 10 years to get here and it’ll take us five years to get started in people.”

However, UCL stem cell biologist Chris Mason warned that “restoring the sight for the ‘three blind mice’ may be far easier than for the ‘farmer’s wife.’”

“Before human clinical trials can commence, the mouse model will require significant optimization, for example increasing the efficiency of new photoreceptors to connect with the damaged retina,” Mason said. “However, there is no doubt that this breakthrough, either directly as the basis of a future cell therapy, or indirectly by expanding our knowledge, will significantly contribute to the fight against blindness.”

Dusko Ilic, a stem cell scientist at King’s College London, said that the work was an important, but small step on a long road to clinical trials.

“We should not get overenthusiastic,” he said.

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