Mon, Feb 20, 2012 - Page 5 News List

Tasmanian devil genome map might help humans

Reuters, CANBERRA

Scientists have mapped the genome of Australia’s endangered Tasmanian devil for the first time and found that deadly facial tumors decimating the species evolve very slowly, making it possible that help might be found before the animals vanish forever.

Not only that, but scientists at Australian National University said on Friday that their discovery, published in the journal PLoS Genetics, could help untangle the process of how human cancers evolve.

Tasmanian devils — popularized by Looney Tunes’ fierce cartoon character “Taz” — are carnivorous marsupials the size of a small dog. The facial tumor disease has ravaged the wild population, confined to Australia’s island state of Tasmania, since being discovered in the mid-1990s.

Scientists believe that unless help is found, the wild population could be extinct within several decades.

However, the mapping carried out by researchers led by Janine Deakin found that, at the genetic level, the tumors evolve very slowly, making it easier to study them — and, possibly, circumvent them.

In addition, this might offer an unusual chance to study how human cancers develop, Deakin added.

“Because we find the devil tumor is evolving so slowly, we can use that as a model to look at cancers in humans. It is a bit more like slowing down the whole process in human cancers,” she said. “In human cancers, the change happens so rapidly we don’t have a chance to look into what the mechanisms are. And we can do that with the devil.”

The Tasmanian devil tumor is spread by skin-to-skin contact and kills by deforming the animals, which then die through starvation or suffocation.

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