The Washington-based US Committee for Refugees, which estimates that there are more than 600,000 internally displaced people in eastern Myanmar, said the new attacks "are of larger scale" than earlier attacks.
"What is also alarming is that 400 tonnes of paddy rice have been burned," said Veronika Martin, an analyst for the group.
Martin described the Karen as "one of the most ignored groups in one of the most difficult humanitarian emergencies," citing high maternal mortality rates among Karen displaced within the country.
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