Sun, Nov 14, 2004 - Page 6 News List

Public funds sought for bird flu vaccine

BE PREPARED There isn't enough money in a vaccine to interest commercial drug companies and yet the disease has the potential to kill millions, experts warn


Health experts and drugs companies on Friday urged rich countries to come up with public funding to spur development of a human vaccine against a pandemic strain of the bird flu virus that could kill millions of people around the world within months.

"We would hope that one of the major messages from this meeting to governments, to support vaccine testing, is going to get across," the World Health Organization's senior flu specialist Klaus Stoehr told journalists after a meeting at the WHO.

Stoehr said that the gathering of 50 top executives from pharmaceutical companies, public health regulators and government officials had agreed to boost cooperation on the issue.

But he warned that private industry alone could not invest about 11 million euros needed in the short term to develop the candidate vaccine needed to inoculate six to seven billion people worldwide in an emergency.

"Without money nothing is going to move with the pandemic vaccine," Stoehr said, emphasizing that 90 percent of the production capacity was in industrialized countries.

Fears of the worldwide spread of a more virulent and deadly strain of influenza have been heightened by recent cases of the recently discovered H5N1 strain of avian flu in Thailand and Vietnam, where the disease has killed 32 people this year.

The WHO estimated that it would take three to six months for a mutated virus to travel around the world, with 25 to 30 percent of the world's population likely to be infected.

About one percent of those who fell ill were likely to die, Stoehr said.

That compared to 2.6 percent death rate during the 1918 flu pandemic, which killed an estimated 21 million people when the world's population was far smaller and international travel was less widespread.

"Practically everybody" -- 6.2 billion people -- would need to be vaccinated in the event of a pandemic, Stoehr added.

Flu vaccines were not available in the three pandemics that hit the world in the last century, most recently in 1968.

Current production capacity for a flu vaccine was about 300 million doses, reaching maybe up to 1.2 billion in a year in an emergency, he estimated.

If development was stretched beyond the two companies - Aventis-Pasteur and Chiron -- currently developing a candidate vaccine for a pandemic strain, it would be possible to produce six billion doses in a year in the best case, the experts estimated.

"Market forces have not brought companies into pandemic vaccine development," Stoehr noted.

Boosted development was also necessary to ensure that the 90 percent of the production capacity located in countries with 12 percent of the world's population would also serve other areas in an emergency, the WHO said.

Luc Hassel of pharmaceutical giant Aventis-Pasteur, and head of an industry task force on regular flu vaccines, said public funding was needed to overcome the lack of a commercial return on pandemic research.

"One of the key messages that we heard in the past two days is that there should be shared responsibilities, otherwise companies will have limited capacity to develop extensive research in this field," he said.

Only the United States has so far invested in pandemic vaccine development.

The Japanese government revealed that it was prepared to support tests on another candidate vaccine by local companies, while France was exploring ways of securing a national pandemic vaccine stockpile.

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