For much of the past century, Asia has been the cradle of influenza, including two of the three major human flu pandemics.
Experts say that given the right conditions, influenza can emerge anywhere, but they say Asia has all the ingredients for spawning flu, such as the outbreak of bird flu now afflicting 10 Asian countries.
All flu viruses probably originate in birds, and the best environment for making the jump to humans is one where densely packed people live closely with birds and animals.
"In Asia we have a huge animal population, a huge bird population and two-thirds of the world's people living there," said Klaus Stohr, chief influenza scientist at the World Health Organization (WHO).
The population of China alone is bigger than that of the whole of Africa, and 80 percent of the new human flu strains the last few decades appeared in China first.
With health officers already leery about a return of SARS, experts are keeping watch on the bird flu in Asia, where the virus has killed millions of chickens, and millions more have been slaughtered in an effort to prevent its spread.
Nine people have died in Vietnam and three in Thailand.
Asia's traditional situation of peasant farmers keeping ducks, chickens and pigs together with the family has long created opportunities for influenza to jump the species barrier.
And now industrial-scale commercial chicken farming is exacerbating the problem, said Robin Weiss, a professor of virology at University College in London.
"We've had nothing like this gigantic chicken breeding in the world before," he said.
As Asia has become not only more populous but also richer and more urbanized, its wealthy citizens demand a more diversified diet, favoring more meat, eggs and dairy products.
To meet that demand, agriculture has undergone a fundamental change, so that even backyard farms have turned almost industrial, filling every square inch with chickens.
"As soon as you have that many animals in one spot you are likely to get into trouble with disease," said Dr. Samuel Jutzi, director of animal production and health at the UN Food and Agriculture Organization (FAO).
From the early 1970s to the early 1990s, per capita consumption of meat, eggs and milk grew about 50 percent in developing countries, leading to big increases in animal herds. Over the last 25 years, the fastest growth has been in the numbers of chickens and pigs, the FAO says.
Asians' fondness for shopping at live animal markets also adds to the chances for flu jumping species, experts say.
And climate may play a role.
"Respiratory viruses, like orchids, do seem to like the Asian climate, because they have influenza viruses nearly all year round. It's not so seasonal as it is in the rest of the world," said John Oxford, a flu expert from Queen Mary School of Medicine in London.
Many scientists believe a major bird migratory pathway from Siberia across Asia could keeps the continent's poultry seeded with the flu virus, which lives naturally in the gut of waterfowl.
Despite Asia's prominent role in spawning flu outbreaks, experts say strains do crop up in other parts of the world.
Scientists are convinced the 1957 Asian flu and 1968 Hong Kong flu pandemics originated in Asia, but there is much debate about where the biggest killer of them all -- the 1918 to 1819 Spanish flu pandemic -- came from.