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Doctors discover another mystery flu-like disease

It isn't SARS, but infectious disease specialists are trying to learn more about a recently discovered virus that some think may be the culprit in many unexplained respiratory illnesses around the world.

The exact prevalence of human metapneumovirus isn't known, but Yale University researchers recently found it in 6.4 percent of retested lab samples from 296 children with respiratory symptoms in late 2001 and early last year, according to a study published yesterday in this month's edition of Pediatrics.

It was also discovered after the fact in about 4 percent of retested specimens taken from Rochester, New York-area adults in 1999 through 2001, University of Rochester researchers reported in a Journal of Infectious Diseases article earlier this year.

While those sites are the only published evidence of the virus in the US, it is thought to be far more prevalent and also has been found in Canada, Europe and Australia.

Like SARS, human metapneumovirus has been associated with flu-like infections and pneumonia-like symptoms, but it does not appear to be as infectious as SARS, said Dr. Jeffrey Kahn of Yale University medical school, senior author of the Pediatrics study.

None of the patients in the Yale or Rochester reports died.

Symptoms may include nasal congestion, wheezing and lung inflammation, and the symptoms may range from mild to serious enough to require hospitalization, Kahn said.

The new virus belongs to the paramyxovirus family, which also includes a common bug called respiratory syncytial virus, or RSV.

The average child gets about 10 respiratory infections by age 1 and many more throughout childhood. Many are caused by cold viruses, influenza or RSV, but doctors aren't able to pinpoint a cause in about a third of the cases, Kahn said.

Human metapneumovirus may be the culprit in many such cases, he said.

Doctors said the virus, nicknamed hMPV, was first identified about two years ago in the Netherlands but likely has been around for a long time. It has less conspicuous features under the microscope than other viruses and may simply have gone undetected or misdiagnosed before.
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