Tim Duncan tallied 23 points and 11 rebounds to power San Antonio to a 111-87 victory over Miami in a rematch of the two NBA finalists from last season.
Tony Parker finished with 17 points and four assists for the Spurs, who snapped their five-game regular-season losing streak against the Heat.
Miami beat the Spurs 113-101 on Jan. 26 at home in the first meeting between the clubs since the Heat beat San Antonio last season to win their second consecutive league title.
San Antonio came close to beating the Heat in the finals, but Miami prevailed with a dynamic last-game win.
Boris Diaw tallied 16 points, eight boards and five assists on Thursday for the Spurs, who have won five straight and eight of nine overall.
Chris Bosh finished with 24 points with seven rebounds, and LeBron James contributed 19 points and eight rebounds for Miami at the AT&T Center.
The Spurs have now won 13 of their past 15 regular-season games against the Heat at home.
James, who had a superb month last month, also had seven assists against the Spurs after scoring 22 points against Houston earlier in the week.
James shot six-of-18 from the field and played a good portion of the second half in foul trouble, while Dwyane Wade finished with 16 points on seven-of-15 shooting.
Miami also shot just 44 percent from the field and committed 20 turnovers, including 10 in the final quarter.
In other play, it was:
‧ Suns 128, Thunder 122
‧ Clippers 142, Lakers 94