In her 17th Wimbledon and 63rd Grand Slam, Williams lost 5-7, 7-6 (7/2), 7-5 in the third round to 2011 champion Petra Kvitova, the sixth seeded Czech, who next plays China’s Peng Shuai.
Bulgarian 11th seed Grigor Dimitrov won a marathon battle with Alexandr Dolgopolov of the Ukraine 6-7 (3/7), 6-4, 2-6, 6-4, 6-1 to make the last 16 for the first time.
He will face unseeded Argentine Leonardo Mayer who beat Russian qualifier Andrey Kuznetsov 6-4, 7-6 (7/1), 6-3.
Former women’s world number one Caroline Wozniacki reached the last 16 for the fourth time with a 6-3, 6-0 win over Croatian 16-year-old Ana Konjuh, the world No. 189.
Belinda Bencic, the reigning Wimbledon girls’ champion, won her delayed second round tie 6-4, 7-5 against America’s Victoria Duval. The 17-year-old Swiss next faces third-seeded Simona Halep of Romania, the French Open runner-up, who clinched a 6-3, 4-6, 6-4 win over Ukrainian qualifier Lesia Tsurenko.
Additional reporting by staff writer