Hull City won 2-0 at Middlesbrough and Stoke City defeated Championship leaders Leicester City 2-1.
Wigan’s trophy defense began in uncertain fashion as they were held to a 3-3 draw by third-tier Milton Keynes Dons, while Millwall, semi-finalists last year, crashed out after an embarrassing 4-1 defeat at fourth-division Southend United.
Bolton Wanderers belatedly exacted revenge for their 3-4 loss to Blackpool in the 1953 final by beating their Championship rivals 2-1, while Leeds United fell to a shock 0-2 defeat at Rochdale.
The lowest-ranked team in the tournament, non-league Macclesfield Town, claimed a 1-1 draw at home to second-tier Sheffield Wednesday thanks to a 72nd-minute equalizer from Steve Williams.
Other results were: Barnsley 1, Coventry City 2; Brighton and Hove Albion 1, Reading 0; Bristol City 1, Watford 1; Doncaster Rovers 2, Stevenage Football Club 3; Grimsby Town 2, Huddersfield Town 3; Ipswich Town 1, Preston North End 1; Kidderminster Harriers 0, Peterborough United 0; Newcastle United 1, Cardiff City 2; Rochdale 2, Leeds United 0; Wigan Athletic 3, Milton Keynes Dons 3; Yeovil Town 4, Leyton Orient 0; Blackburn Rovers 1, Manchester City 1.
Two games, Bournemouth versus Burton and Charlton against Oxford, were postponed due to waterlogged pitches.
Set to be played yesterday were Derby against Chelsea, Liverpool versus Oldham, Manchester United and Swansea, Nottingham Forest against West Ham, Port Vale versus Plymouth and Sunderland up against Carlisle.