In Cincinnati, Ohio, Brandon Phillips drove in a pair of runs with a bases-loaded single in the eighth inning as the Reds ended their five-game losing streak by beating the Philadelphia Phillies 4-2.
Cincinnati’s five-game slide matched their longest slump from last season, when they won the National League Central.
In the American League, Mark Buehrle pitched in and out of trouble into the seventh inning to beat his former team, while J.P. Arencibia and Maicer Izturis hit solo homers as the Toronto Blue Jays topped the Chicago White Sox 4-3.
Buehrle (1-0) went 6-1/3 innings in his first career start against the White Sox, allowing two runs and nine hits. The left-hander walked two and struck out three.
In other AL games, the Minnesota Twins downed the Los Angeles Angels 8-2 and the Oakland Athletics trounced the Houston Astros 11-2.
In the National League, the St Louis Cardinals defeated the Pittsburgh Pirates 10-6 and the Washington Nationals were 10-3 winners over the Florida Marlins.
Jon Jay and Matt Holliday each had two hits and two RBIs as St Louis jumped on Pittsburgh early.
Allen Craig doubled and drove in three runs for the Cardinals, who knocked around James McDonald (1-2) with a seven-run second inning. McDonald gave up eight runs, three earned, and walked two in 1-1/3 innings, the shortest start of his career.
Lance Lynn (2-0) labored through five innings to get the win.
Starling Marte had three hits and Neil Walker homered for the Pirates, who had their three-game winning streak snapped.
Meanwhile, Jordan Zimmermann pitched a six-hitter for his third victory of the season as Washington bounced back from a humbling weekend to beat Miami.
Ryan Zimmerman hit his first home run and had four RBIs to lead a 16-hit outburst. Zimmermann (3-0) struck out six, walked one and threw 102 pitches in his second career complete game.
The Nationals were outscored 18-5 while being swept in a three-game series at home against Atlanta. They took out any lingering frustration on the Marlins (2-11), who came into the game tied for the worst record in the majors.