Lazio overcame Stuttgart with goals in each half from Brazilian Ederson and Nigerian midfielder Ogenyi Onazi, who picked up the ball in his own half, advanced almost unchallenged and chipped the ball over Sven Ulreich.
Goalkeeper Rob Elliot made a brilliant second-half save from Samuel Eto’o as Newcastle United held out for a dour goalless draw in bitterly cold conditions away to Anzhi.
With the temperature well below zero, Anzhi started brightly, but lost momentum after Brazilian playmaker Willian, signed from Shakhtar Donetsk for 35 million euros (US$46 million) at the start of last month, went off injured after 22 minutes.
Zenit were also goalless until the last 10 minutes at Basel, then Chilean midfielder Marcelo Diaz scored from close range for the Swiss champions.
Veteran Alexander Frei converted a stoppage-time penalty for a foul on Mohamed Salah by Luis Neto, who was also sent off.
Cameroon forward Pierre Webo scored an 81st-minute goal to give Fenerbahce their 1-0 win at Plzen.